中国现代医学杂志2018，Vol.28Issue(5)：7-10,4.DOI:10.3969/j.issn.1005-8982.2018.05.002
GBE对COPD大鼠血清和肺泡灌洗液中IL-1、IL-8含量的影响
Effect of Ginkgo biloba extract on content of IL-1 and IL-8 in serum and bronchial alveolar lavage fluid in rat model of COPD
摘要
Abstract
Objective To study the effect of Ginkgo biloba extract (GBE) on the content of IL-1 and IL-8 in the serum and bronchial alveolar lavage fluid (BALF) in rat model of chronic obstructive pulmonary disease (COPD). Methods In this study, 90 Wistar rats were randomly divided into groups A, B, C, D, E and F with 15 rats in each group. The rat model of COPD was established by exposure to cigarette smoke and cold air stimulation composite factors in the groups B, C, D, E and F. The rats in the groups C and D were given intraperitoneal injection of GBE from day l to day l4 and day 29 to day 42 respectively. The rats in the groups E and F were given intraperitoneal injection of Erythromycin from day l to day l4 and day 29 to day 42 respectively. The serum and BALF of each group were collected after 43 days. Then the content of IL-1 and IL-8 in the serum and BALF was measured. Results Compared with the group B, the serum content of IL-1 and IL-8 and the content of IL-1 in the BALF were lower in the groups A, C, D, E and F (P < 0.05). In reducing serum IL-1 level, early GBE intervention was better than late GBE intervention. In reducing serum and BALF IL-1 and IL-8 levels, GBE had no significant difference with Erythromycin (P > 0.05). Conclusions GBE can inhibit the airway and systemic inflammation of COPD.关键词
银杏叶提取物/慢性阻塞性肺疾病/白细胞介素-1/白细胞介素-8Key words
Ginkgo biloba extract/chronic obstructive pulmonary disease/IL-1/IL-8分类
医药卫生引用本文复制引用
谭玉萍,张鹏飞,冯玉清,杨益宝,梁炜,杨红梅,梁爱武,邓祯..GBE对COPD大鼠血清和肺泡灌洗液中IL-1、IL-8含量的影响[J].中国现代医学杂志,2018,28(5):7-10,4.基金项目
国家自然科学基金(No :81260005) （No :81260005）
