中国现代医学杂志2018，Vol.28Issue(5)：23-28,6.DOI:10.3969/j.issn.1005-8982.2018.05.005
MRI评价抗肿瘤中药康莱特注射液疗效的实验研究
Evaluation of efficiency of Kanglaite in treatment of tumor by diffusion magnetic resonance
李晓琴 1朱红革 1刘春玲1
作者信息
- 1. 新疆医科大学附属肿瘤医院 肺内二科,新疆 乌鲁木齐 830011
- 折叠
摘要
Abstract
Objective To evaluate whether the functional MRI can be used to reflect the change of tumor angiogenesis after drug treatment, and to obtain the related semi-quantitative and quantitative parameters by diffusion magnetic resonance technique. Methods Subcutaneous transplantation model of colorectal cancer was constructed in 20 nude mice. Kanglaite was used for the treatment of colorectal cancer in the nude mice. Microvascular density (MVD), vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) of the transplanted tumors were monitored. The therapeutic efficiency and MRI monitoring results were evaluated. Combining diffusion magnetic resonance with the pharmacokinetic model, the semi-quantitative and quantitative parameters were obtained, the efficiency of the medicine was evaluated. Half of the nude mice were sacrificed to finish the immunohistochemical staining. The correlations between the pathological findings and the parameters were analyzed. Results After Kanglaite injection treatment, the proliferation rate of human colon cancer HT-29 cells significantly decreased by 33.113％ compared to the control group (P < 0.05). Compared with the control group, the apoptosis rate of HT-29 cells increased by 28.243％ (P < 0.05). The correlation analysis between pathological examination and diffusion magnetic resonance parameters showed that ADCperf, ADC3b and ADC10b were positively correlated with MVD (P < 0.05). Conclusions The quantitative parameters of diffusion magnetic resonance are closely correlated with immunohistochemical results in Kanglaite treatment of human colon cancer in nude mice.关键词
结肠癌/裸鼠/康莱特注射液/磁共振功能成像/疗效评价Key words
colon cancer/nude mice/Kanglaite/diffusion magnetic resonance/efficiency evaluation分类
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李晓琴,朱红革,刘春玲..MRI评价抗肿瘤中药康莱特注射液疗效的实验研究[J].中国现代医学杂志,2018,28(5):23-28,6.
