中国现代医学杂志2018，Vol.28Issue(5)：29-32,4.DOI:10.3969/j.issn.1005-8982.2018.05.006
Smad4在老年喉鳞癌患者中的表达及其临床意义
Expression of Smad4 in laryngeal squamous cell carcinoma of elderly patients and significance
摘要
Abstract
Objective To observe the expression of Smad4 protein in laryngeal squamous cell carcinoma of elderly patients and investigate the relationships between Smad4 protein expression and clinical pathological features. Methods Immunohistochemical technique was used to detect the expression of Smad4 protein in 65 tissues of laryngeal squamous cell carcinoma and paired para-carcinoma tissues. Results The positive rate of Smad4 in the laryngeal squamous cell carcinoma was obviously lower than that in the para-carcinoma tissues (P < 0.05). The Smad4 protein expression in the laryngeal squamous cell carcinoma had correlations with differentiated degree of laryngeal squamous cell carcinoma and lymph node metastasis (P < 0.05). Conclusions Smad4 may contribute to the carcinogenesis and development of laryngeal squamous cell carcinoma and play an important role in the process of differentiation, infiltration and metastasis of laryngeal squamous cell carcinoma.关键词
喉鳞状细胞癌/Smad4/免疫组织化学法Key words
laryngeal squamous cell carcinoma/Smad4/immunohistochemistry分类
医药卫生引用本文复制引用
卢岩,康健..Smad4在老年喉鳞癌患者中的表达及其临床意义[J].中国现代医学杂志,2018,28(5):29-32,4.基金项目
山西省研究生教育创新项目(No :2015 BY32) （No :2015 BY32）
