中国现代医学杂志2018，Vol.28Issue(5)：33-37,5.DOI:10.3969/j.issn.1005-8982.2018.05.007
P53、Her-2和Ki67在甲状腺乳头状癌中的表达及其临床意义
Expressions of p53, Her-2 and Ki67 in thyroid papillary carcinoma and their clinical significance
摘要
Abstract
Objective To investigate the expressions of p53, Her-2 and Ki67 in thyroid papillary carcinomas (TPC) and their significance. Methods The expressions of p53, Her-2 and Ki67 in 128 cases of TPC, 56 cases of thyroid adenomas and 9 cases of normal thyroid tissues were detected by immunohistochemical technique. Results There was no positive expression of p53, Her-2 or Ki67 in the normal thyroid tissues. The positive expression rate of p53 in the TPC was 85.15％ (109/128) which was significantly higher than 26.78％ (15/56) of the thyroid adenomas (P < 0.05). The positive expression rate of Her-2 in the TPC was 25.78％ (33/128) which was significantly higher than 12.49％ (7/56) of the thyroid adenomas (P < 0.05). The positive rates of Ki67 expression in the TPC and the thyroid adenomas were 38.28％ (49/128) and 23.21％ (13/56) respectively, the statistical analysis showed no significant difference between the two groups (P > 0.05). Conclusions P53 and Her-2 expressions have certain guiding significance for the evaluation of the occurrence, development and prognosis of thyroid papillary carcinoma. Ki67 has no definite clinical significance in differential diagnosis of TPC.关键词
乳头状癌/抗癌基因/人类表皮生长因子受体2/细胞增殖抗原Key words
thyroid papillary carcinoma/p53/Her-2/Ki67分类
医药卫生引用本文复制引用
贾巍,尹长恒..P53、Her-2和Ki67在甲状腺乳头状癌中的表达及其临床意义[J].中国现代医学杂志,2018,28(5):33-37,5.基金项目
河北省衡水市科技局科研基金(No :14021A) （No :14021A）
