中国现代医学杂志2018，Vol.28Issue(5)：87-91,5.DOI:10.3969/j.issn.1005-8982.2018.05.017
合并AECOPD髋关节置换患者围手术期PCT、CRP的相关性研究
Regression analysis of PCT and CRP in hip-joint replacement surgery of patients with AECOPD
黄沛彦 1顾军 1吴俊国 1何军 1童文卿 1何益群 1王明海1
作者信息
- 1. 复旦大学附属上海市第五人民医院 骨科,上海 200240
- 折叠
摘要
Abstract
Objective To explore the dynamic changes of perioperative serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) receiving hip-joint replacement surgery and to analyze its clinical significance. Methods Totally 107 patients with AECOPD who received hip-joint replacement surgery were selected from our hospital. Venous blood was drawn on the 1st, 3rd, 5th, 7th and 9th day after admission. Serum CRP and PCT levels of all patients were dynamically detected. Linear regression analysis was performed on logarithms (LN) of the results. At the same time, multiple linear regression analysis of the subgroups accompanied with pneumonia or not was carried out. Results The patients'' LN (PCT) was associated with time (day) with statistical significance (P < 0.05), and the regression equation was: LN(PCT) = 1.97 -0.42day. At the same time LN(CRP) was associated with time (day) (P < 0.05), the regression equation was: LN (CRP) = 4.93 - 0.28day. When the normal values were substituted into the equations, it was obtained that the time for PCT to recovery to normal value in the AECOPD patients was 3.84 days earlier than that of CRP. And subgroup analysis was carried out according to whether the patients were accompanied with pneumonia, it was obtained that LN (PCT) and LN (CRP) were associated with the time (day) and whether accompanied with pneumonia (pneu),respectively (P < 0.05). The equation of PCT was: LN(PCT) = 1.80 - 0.42day + 0.34pneu, while the equation of CRP was: LN(CRP) = 4.79 - 0.28day + 0.26pneu. When the normal values were substituted into the equations, it was obtained that the time for PCT to recovery to normal value in the group A (accompanied with pneumonia) was 0.810 day earlier than that of the group B (not accompanied with pneumonia). And that of CRP was earlier by 0.928day. Conclusions For AECOPD patients accompanied with pneumonia before hip-joint replacement surgery, the recovery time of serum PCT and CRP is longer. At the same time, in the recovery process of AECOPD patients serum PCT is more sensitive than CRP. Dynamic monitoring of PCT can help to earlier clarify the situation of infection control and carry out hip replacement surgery as early as possible.关键词
髋关节置换/围手术期/降钙素/C反应蛋白/慢性阻塞性肺疾病急性加重期Key words
hip-joint replacement/perioperative period/procalcitonin/C-reactive protein/acute exacerbation of chronic obstructive pulmonary disease分类
医药卫生引用本文复制引用
黄沛彦,顾军,吴俊国,何军,童文卿,何益群,王明海..合并AECOPD髋关节置换患者围手术期PCT、CRP的相关性研究[J].中国现代医学杂志,2018,28(5):87-91,5.
