中国医学前沿杂志（电子版）2017，Vol.9Issue(11)：62-65,4.DOI:10.12037/YXQY.2017.11-12
CD64指数、sTREM-1、CD54水平对社区获得性肺炎患儿病情评估的价值
The value of CD64 index, sTREM-1 and CD54 levels in the assessment of children with community acquired pneumonia
摘要
Abstract
Objective To study the significance of CD64 index, soluble myeloid cells trigger receptor-1 (sTREM-1) and CD54 levels in the diagnosis and treatment of children with community acquired pneumonia (CAP).Method 377 cases of CAP children diagnosed and treated in our hospital from May 2014 to May 2016 were selected as the subjects. According to the type of infection pathogen, they were divided into bacteria-infected group, mycoplasma-infected group and virus-infected group. The bacteria-infected group was divided into mild group and severe group according to the severity of the disease. 30 healthy children during the same period were selected ascontrol group. STREM-1 level, CD54 level and CD64 index of the selected CAP children were detected the first day after admission, respectively, those indexs of health checkup children were detected on physical examination day.Result The CD64 index and sTREM-1 level of bacteria-infected group were significantly increased in comparison with control group (P<0.05). In the mycoplasma-infected group, the CD64 index significantly increased (P<0.05). CD54 levels increased in all of the three infection groups but was more significant in the virus-infected group (P<0.05). There were significant differences compared with the bacteria-infected group and the mycoplasma-infected group (t=26.451,P=0.024;t=28.302,P=0.022). According to the results of consecutive detection, CD64 index, sTREM-1, CD54 levels declined in accordance with the alleviation of the disease (P<0.05). On the other side, CD64 index, sTREM-1, CD54 levels were significantly higher in mild group than severe group (P<0.05).Conclusion The level of CD64 index, sTREM-1 and CD54 can provide guidance for the differential diagnosis and disease evaluation of children with CAP, and provide reference for clinical rational use of drugs.关键词
社区获得性肺炎/儿童/CD64指数/可溶性髓系细胞触发受体1/CD54Key words
Community acquired pneumonia/Children/CD64 index/Soluble myeloid cells trigger receptor-1/CD54引用本文复制引用
吴佳辉,田亚杰,孟伟..CD64指数、sTREM-1、CD54水平对社区获得性肺炎患儿病情评估的价值[J].中国医学前沿杂志（电子版）,2017,9(11):62-65,4.基金项目
河北省科学技术研究与发展计划项目(15003506821) （15003506821）
