中成药2018，Vol.40Issue(1)：61-65,5.DOI:10.3969/j.issn.1001-1528.2018.01.011
通脉汤对老年股骨粗隆间骨折患者围术期PLT、PAgR、D-D和TEG的影响
Effects of Tongmai Decoction on PLT, PAgR, D-D and TEG in elderly patients with intertrochanteric fracture in perioperative period
摘要
Abstract
AIM To investigate the effects of Tongmai Decoction on PLT,PAgR,D-D and TEG in elderly patients with intertrochanteric fracture in perioperative period.METHODS One hundred and fifteen recruited patient subjects were randomly divided into two groups.Fifty-seven cases in the control group were treated with Low Molecular Weight Heparins Calcium Injection,and 58 cases in the treatment group were intervened with both Low Molecular Weight Heparins Calcium Injection and Tongmai Decoction.The preoperative and postoperative dynamic changes of PLT,PAgR,D-D and TEG (R value,K value,alpha angle,MA),and adverse drug reactions in the two groups were detected 1,3,7 d prior to,and after the treatments,respectively.RESULTS No statistically significant difference between the two groups' PLT,PAgR and D-D contents were observed before the operation (P ＞ 0.05).The levels of PLT,PAgR and D-D in both groups increased one day after the operation with similar change degree (P ＞ 0.05).On the 3rd and 7th days after the surgery,the PLT,PAgR and D-D contents in the two groups began to drop,and the decline in the treatment group was more significant (P ＜ 0.05).No significantly different TEG (R value,K value,alpha angle,MA) between the two groups was noticed before the operation (P ＞ 0.05).Patients of both groups displayed their R value,K value decrease,and alpha Angle,MA increase (P ＞ 0.05) one day after the operation with similar change degree.Their R value,K value increased,and alpha angle,MA decreased,and as well as the statistically significant change between the two groups were discovered on the 3rd and 7th postoperative days (P ＜ 0.05).CONCLUSION Tongmai Decoction can effectively reduce blood hypercoagulability and prevent deep venous thrombosis in terms of PLT,PAgR,D-D and TEG (R value,K value,alpha angle,MA) improvement in elderly patients with intertrochanteric fracture in perioperative period.关键词
通脉汤/PLT/PAgR/D-D/TEG/股骨粗隆间骨折Key words
Tongmai Decoction/PLT/PAgR/D-D/TEG/intertrochanteric fracture分类
医药卫生引用本文复制引用
梁伟春,黎清斌,劳永锵,王明爽,胡永波..通脉汤对老年股骨粗隆间骨折患者围术期PLT、PAgR、D-D和TEG的影响[J].中成药,2018,40(1):61-65,5.基金项目
佛山市医学类科技攻关立项课题(2014AB00323) （2014AB00323）
