中成药2018，Vol.40Issue(1)：66-70,5.DOI:10.3969/j.issn.1001-1528.2018.01.012
3种丹皮酚凝胶经皮渗透性能的比较
Comparison of three paeonol gels in their percutaneous penetration performance
摘要
Abstract
AIM To compare the percutaneous penetration performance of three paeonol gels.METHODS Franz diffusion cell method was applied to investigating the penetration and retention behaviors of eutectic mixturebased nanoemulsion,ordinary nanoemulsion and saturated solution gels onto mouse skins in vitro.The retention and permeation amounts in stratum corneum and hair follicles of volunteers smeared with gels were compared by tape stripping method.RESULTS The accumulative permeation and retention amounts of various gels onto mouse skins in vitro were in sequence of eutectic mixture-based nanoemulsion gel ＞ ordinary nanoemulsion gel ＞ saturated solution gel.The main retention of all the three gels was observed on the volunteers' skin surface,and the permeation amounts of eutectic mixture-based nanoemulsion,ordinary nanoemulsion gels,and their accumulative permeation amounts in stratum corneum and hair follicles were significantly higher than those of saturated solution gel (P ＜0.05).CONCLUSION Nanoemulsion technology can significantly promote the percutaneous penetration performance of paeonol.关键词
丹皮酚/凝胶/经皮渗透/Franz扩散池法/胶带剥离法Key words
paeonol/gels/percutaneous penetration/Franz diffusion cell method/tape stripping method分类
医药卫生引用本文复制引用
蔡雅琴,冯军,侯延辉,王文苹..3种丹皮酚凝胶经皮渗透性能的比较[J].中成药,2018,40(1):66-70,5.基金项目
国家自然科学基金资助项目(81760713) （81760713）
