中成药2018，Vol.40Issue(1)：87-92,6.DOI:10.3969/j.issn.1001-1528.2018.01.016
水飞蓟素固体分散体的制备及5种成分的溶出度
Preparation of silymarin solid dispersions and dissolution rates of five constituents
摘要
Abstract
AIM To prepare silymarin solid dispersions and to evaluate the dissolution rates of five constituents.METHODS Taking F68 and PVPk30 as a combined carrier,the solid dispersions were prepared by solvent fusion method.Then the effects of combined carrier ratio and drug-carrier ratio on dissolution rates of silybin,isosilybin,silydianin,silycristin and taxifolin were investigated.RESULTS The optimal conditions were determined to be 1 ∶ 3 for combined carrier ratio,and 1 ∶ 5 for drug-carrier ratio.These five constituents displayed much higher dissolution rates in solid dispersions than those in raw medicine and physical mixture (silymarin-carrier).CONCLUSION Solid dispersions can significantly increase the dissolution rates of effective components in silymarin.关键词
水飞蓟素/固体分散体/制备/化学成分/溶出度/溶剂熔融法Key words
silymarin/solid dispersions/preparation/chemical constituents/dissolution rates/solvent fusion method分类
医药卫生引用本文复制引用
孙欣荣,张敏新,杨海跃,吴珏,宋洪涛,刘志宏..水飞蓟素固体分散体的制备及5种成分的溶出度[J].中成药,2018,40(1):87-92,6.基金项目
福建省自然科学基金项目(2015J01491) （2015J01491）
