安徽农业科学2018，Vol.46Issue(3)：3-5,3.
斑鸠菊固体分散体滴丸制备工艺研究
Study on Preparation Technology for Solid Dispersion Dropping Pills of Vernonia esculenta
摘要
Abstract
[Objective] The research aimed to research the preparation technology for Vernonia esculenta dropping pills.[Method] The solid dispersion drop pills of Vernonia esculenta were prepared by the solid dispersion technology combined with droplet technology.With the dissolution time limit,weight difference and appearance quality as the comprehensive evaluation index,the ratio of PEG4000-PEG6000 and extractmatrix,dropping temperature and speed were investigated,the preparation technology of solid dispersion dropping pills of Vernonia esculenta was optimized.[Result] The condition for preparation of solid dispersion dropping pills of Vernonia esculenta were:the temperature of condensation medium(simethicone 100)of 20 ℃,PEG4000-PEG6000 (3∶1),extract-matrix (1∶7),dropping temperature 80 ℃,dropping speed 20 drops/min.[Conclusion] The preparation technology for the solid dispersion dropping pills of Vernonia esculenta is simple and feasible,it can provide a reference for industrial production.关键词
斑鸠菊/滴丸/成型工艺/固体分散剂/聚乙二醇Key words
Vernonia esculenta/Dropping pills/Preparation technology/Solid dispersion/Polyethylene glycol分类
医药卫生引用本文复制引用
章慧,陈新,史茹茹..斑鸠菊固体分散体滴丸制备工艺研究[J].安徽农业科学,2018,46(3):3-5,3.基金项目
国家自然科学基金项目(31370369). （31370369）
