安徽医科大学学报2017，Vol.52Issue(11)：1704-1708,5.DOI:10.19405/j.cnki.issn1000-1492.2017.11.027
SPAG5在原发性乳腺癌中的表达与TEC方案新辅助化疗敏感性的关系
Correlation between expression of SPAG5 and the sensitivity to TEC regimens neoadjuvant chemotherapy in primary breast cancer
摘要
Abstract
Objective To explore the expression of sperm associated antigen5 (SPAG5) and discuss the relationship between expression,clinicopathologic characteristics and sensitivity to neoadjuvant chemotherapy in primary breast cancer.Methods The tissue of 107 patients treated with TEC(T:Docetaxel E:Epirubicin C:Cytoxan) neoadjuvant chemotherapy with primary breast cancer were collected to measure the expression of SPAG5 by immunohistochemical staining.Data were analysed to investigate the correlation to clinicpathologic factors and chemotherapyresponse.Results The over-expressed rate of SPAG5 from tissues of primary breast cancer was 48.6％ (52/ 107) and proved to be positively correlated to the over-expression of human epidermal growth factor receptor-2 (P =0.000) and proliferating cell nuclear antigen (P =0.019).However there were no significant correlations between age,tumor size,TNM stage,histological grading,lymphnode status and the expression level of estrogen receptor and progesterone receptor.The overall objective response(OR) rate was 70.1％ (75/107) and the pathologic complete response(pCR) rate was 9.3％ (10/107)after neoadjuvant chemotherapy.The objective response rates were 82.7％ (43/52) in SPAG5 over-expression group and 56.1％ (32/57)in low-expression group,and the difference was statistically significant(P =0.006).The rates of pCR were 15.4％ (8/44) in group of SPAG5 over-expression and 3.6％ (2/53)in low-expression group,which proved significantly different by Fisher exact probability test(P =0.048).The OR rate and pCR rate of patients with over-expression of SPAG5 were higher than low-expression ones.Conclusion SPAG5 as a tumor proliferation index,its expression status for breast cancer patients with TEC regimen neoadjuvant chemotherapy has a predictive effect.关键词
SPAG5/增殖指标/乳腺肿瘤/新辅助化疗/TECKey words
SPAG5/proliferation/breast neoplasms/neoadjuvant chemotherapy/TEC分类
医药卫生引用本文复制引用
王俊艳,吴正升,裴静,任敏,王本忠..SPAG5在原发性乳腺癌中的表达与TEC方案新辅助化疗敏感性的关系[J].安徽医科大学学报,2017,52(11):1704-1708,5.基金项目
国家自然科学基金(编号:81472493) （编号:81472493）
安徽省自然科学基金(编号:1608085MH238) （编号:1608085MH238）
