安徽医科大学学报2017，Vol.52Issue(12)：1871-1875,5.DOI:10.19405/j.cnki.issn1000-1492.2017.12.027
红细胞分布宽度对系统性红斑狼疮疾病活动度评估的临床价值
The clinical value of red blood cell distribution width for assessing the severity of systemic lupus erythematosus
摘要
Abstract
Objective To analyze the relationship between the red blood cell distribution width(RDW) and the severity of newly diagnosed patients with systemic lupus erythematosus (SLE).Methods The medical records of 181 patients of newly diagnosed systemic lupus erythematosus and 190 healthy controls were retrospectively analyzed,such as C-reactive protein(CRP),erythrocyte sedimentation rate (ESR),complement,immunoglobulin and RDW.In addition,SLE disease activity index 2000(SLEDAI-2K),a global index based on the symptoms and laboratory findings,was calculated according to medical records for each patient.The RDW index between different groups were compared and the relationship between RDW and the SLEDAI-2K score were analyzed.Results RDW was significantly higher in patients with SLE than that of control group(t =16.36,P ＜0.001).RDW was positively correlated with serum ESR,CRP and SLEDAI-2K (r =0.628,0.663,0.725,P ＜ 0.001) but negatively correlated with serum C3 and C4 (r =-0.348,-0.273,P ＜ 0.001).A significant difference in RDW was found between different stages of activity groups in patients with SLE(F =99.66,P ＜0.001) and there were also differences between any two for the four groups(P ＜ 0.05).Conclusion RDW may be a useful inflammatory index to estimate the disease activity of newly diagnosed patients with SLE.关键词
系统性红斑狼疮/红细胞分布宽度/疾病活动度Key words
systemic lupus erythematosus/red blood cell distribution width/disease activity分类
医药卫生引用本文复制引用
周廷栋,杨凯,陈礼文,管世鹤..红细胞分布宽度对系统性红斑狼疮疾病活动度评估的临床价值[J].安徽医科大学学报,2017,52(12):1871-1875,5.基金项目
国家自然科学基金(编号:81171662) （编号:81171662）
安徽医科大学校科研基金(编号:2017xkj042) （编号:2017xkj042）
