安徽医科大学学报2017，Vol.52Issue(12)：1880-1882,3.DOI:10.19405/j.cnki.issn1000-1492.2017.12.029
IL-2、IL-17和TNF-α水平与合并原发性甲状腺功能减退症的不孕症患者相关性研究
Correlation between IL-2, IL-17 and TNF-α levels and infertility patients with primary hypothyroidism
摘要
Abstract
To investigate the involvement of interleukin(IL)-2,IL-17,and TNF-α in infertility with hypothyroidism.The baseline scram levels of IL-2,IL-17,and TNF-α were measured by ELISA.32 infertility patients with hypothyroidism,53 infertility healthy patients with normal thyroid function,and 30 healthy subjects were selected to determine the associated changes of cytokines.Serum IL-2 levels were similar in infertility patients with normal thyroid function and healthy subjects compared with healthy subjects group,but higher compared with infertility patients with hypothyroidism group (P ＜ 0.05).Serum IL-17 level were gradually increased in infertility patients with hypothyroidism,infertility healthy patients with normal thyroid function,and 30 healthy subjects(P ＜ 0.01).Serum TNF-α were similar in infertility patients with hypothyroidism and with normal thyroid function,while higher compared with healthy subjects (P ＜0.01).The serum level of IL-2 was decreased in infertility patients with hypothyroidism,while the serum levels of IL-17 and TNF-α were increased.In addition,IL-17 might serve as a useful biomarker for evaluating infertility with Hypothyroidism.关键词
白细胞介素/肿瘤坏死因子/甲状腺功能减退/不孕症Key words
IL/TNF/hypothyroidism/infertility分类
医药卫生引用本文复制引用
许敏,惠灿灿,王佑民,陈明卫,邓大同..IL-2、IL-17和TNF-α水平与合并原发性甲状腺功能减退症的不孕症患者相关性研究[J].安徽医科大学学报,2017,52(12):1880-1882,3.基金项目
安徽省高校省级自然科学研究项目(编号:KJ2013Z112) （编号:KJ2013Z112）
安徽省自然科学基金(编号:1608085MH207) （编号:1608085MH207）
