首页|期刊导航|癌症（英文版）|Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

Rong Geng Jiaxin Lin Lin Qiu Wenlin Huang Shuai Chen Xin Tan Zhixiang Zuo Jiangxue Wu Zhizhong Pan Wei Shi Ranyi Liu Chen Yao Gaoyuan Wang

癌症（英文版）2017，Vol.36Issue(12)：726-736,11.

癌症（英文版）2017，Vol.36Issue(12)：726-736,11.DOI:10.1186/s40880-017-0228-1

Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

Rong Geng ¹Jiaxin Lin ²Lin Qiu ¹Wenlin Huang ²Shuai Chen ¹Xin Tan ²Zhixiang Zuo ¹Jiangxue Wu ²Zhizhong Pan ³Wei Shi ¹Ranyi Liu ²Chen Yao ⁴Gaoyuan Wang¹

作者信息

1. State Key Laboratory of Oncology in South China,Collaborative Innovation Center of Cancer Medicine,Sun Yat-sen University Cancer Center,651 Dong-feng Road East,Guangzhou 510507,Guangdong,P.R.China
2. Department of Experimental Research,Sun Yat-sen University Cancer Center,Guang-zhou 510060,Guangdong,P.R.China
3. Guangdong Provincial Key Laboratory of Tumor-Targeted Drugs and Guangzhou Enterprise Key Laboratory of Gene Medicine,Guangzhou Doublle Bioproducts Co.Ltd.,Guangzhou 510507,Guangdong,P.R.China
4. Guangdong Esophageal Cancer Institute,Sun Yat-sen University Cancer Center,Guangzhou 510060,Guangdong,P.R.China
折叠

摘要

关键词

Synthetic lethal/Colorectal cancer/Ring finger protein 183/Mitogen-activated extracellular signal-regulated kinase 1/2/Trametinib

Key words

Synthetic lethal/Colorectal cancer/Ring finger protein 183/Mitogen-activated extracellular signal-regulated kinase 1/2/Trametinib

引用本文复制引用

Rong Geng,Jiaxin Lin,Lin Qiu,Wenlin Huang,Shuai Chen,Xin Tan,Zhixiang Zuo,Jiangxue Wu,Zhizhong Pan,Wei Shi,Ranyi Liu,Chen Yao,Gaoyuan Wang..Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells[J].癌症（英文版）,2017,36(12):726-736,11.

基金项目

This study was supported by the National Natural Science Foundation of China (Nos. 81672744, 81472252), Science and Technology Project of Guang-dong Province (No. 2016A020217007), and Guangdong Esophageal Cancer Institute (No. M201606). （Nos. 81672744, 81472252）

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ISSN：1000-467X

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