分析化学2018，Vol.46Issue(2)：246-253,后插5-后插10,14.DOI:10.11895/j.issn.0253-3820.170031
多菌灵与3种环糊精的识别研究
Study on Inclusion Behavior of Carbendazim with Cyclodextrins
摘要
Abstract
Hydrophobic medicine carbendazim,come into inclusion compounds with β-cyclodextrin(β-CD),2-hydroxypropyl-β-CD (2-Hp-β-CD) and 2,6-dimethyl-β-CD(Me-β-CD),were made by solvent method.By investigating the inclusion behaviors of these three cyclodextrins combined with carbendazim using 1H NMR,2D rotating frame overhause effect spectroscopy (ROESY) and diffusion ordered spectroscopy,the possible ways of combinations and the recognition ratio of this three inclusion compounds,Dβ-CD=2.516×10-10m2/s,D2-Hp-β-CD=1.676×10-10m2/s,DMe-β-CD=2.046×10-10m2/s,were obtained.According to X-ray power diffraction,thermogravimetric analysis,infrared spectroscopy and scanning electron spectroscopy characterization,it was found that the characteristic diffraction peaks changed after carbendazim and cyclodextrin formed into inclusion compounds,and the characteristic diffraction peak of carbendazim at 10.4°,21.2°,25.8°,31.5°(2θ) lost or disappear.The pyrolysis temperature of carbendazim was 197.5℃,and would be higher than 260℃ after it formed inclusion complex.The infrared spectrum also showed that the oscillation peaks of inner cyclodextrin cavum apparently reduced after carbendazim combined,which demonstrated that the position of water molecules inside cyclodextrin cavum were occupied by the carbendazim molecules.With the help of SEM,the appearances of inclusion were different from a single carbendazim molecule,which manifested a new structure appeared.关键词
多菌灵/环糊精/核磁共振/包合物Key words
Carbendazim/Cyclodextrins/Nuclear magnetic resonance/Inclusion引用本文复制引用
孙伟,厍梦尧,马思悦,陈娇,史真,李剑利..多菌灵与3种环糊精的识别研究[J].分析化学,2018,46(2):246-253,后插5-后插10,14.基金项目
本文系国家自然科学基金项目(Nos.21572177,21673173, J1210057 )和陕西省自然科学基金项目(Nos.2015J003,2016JZ004)资助This work was supported by the National Natural Science Foundation of China (Nos.21572177, 21673173, J1210057) and the Natural Science Foundation of Shaanxi Province, China (Nos.2015J003,2016JZ004). （Nos.21572177,21673173, J1210057 ）
