广西医科大学学报2017，Vol.34Issue(12)：1699-1702,4.DOI:10.16190/j.cnki.45-1211/r.2017.12.005
高脂血症模型大鼠血清总睾酮及性激素结合蛋白水平变化对勃起功能的影响
Effects of serum total testosterone and sex hormone-binding globulin levels on erectile function in hyperlipidaemia rats
摘要
Abstract
Objective:To investigate the correlation between the serum total testosterone (T)and sex hormone-binding globulin (SHBG)levels and erectile function in hyperlipidaemia rats.Methods:29 male SD rats were randomly divided into a control group(n=14)and a high-fat group(n=15).The rats in the high-fat group were fed with lipid rich foods for 24 weeks,and then were given lipid rich food contained 0.2％ oxygen pyrimidine to keep feeding.Rats in the control group were fed with normal diets.After 36 weeks of feeding,the levels of total cholesterol (TC)and low-density lipoprotein cholesterin (LDL-C)were measured.The hyperlipidaemia rats were subcutaneously injected with apomorphine (APO)in order to induce penile erection.The times of erection,erection rate and the levels of T and SHBG in serum were compared between the two groups.The pathological changes of cavernous tissues were observed.Results:The erection times,erection rate,and the serum levels of T and SHBG were significantly lower in the high-fat group than those in the control group (P＜ 0.05).Compared with the control group,a remarkable reduction in cavernous sinus,an uneven distribution of smooth muscle in cavernous tissue of the high-fat group rats,as well as disrupted continuity and integrity in smooth muscles were observed by hematoxylin-eosin(HE)staining.Additionally,EVG staining revealed that the collagen fibers in the corpora cavemosa increased,while the elastic fibers and smooth muscle fibers decreased in rats with hyperlipidaemia.Conclusion:Hypedipidemia could induce damaged structure in cavernous tissue and marked reduction of serum T and SHBG levels in rats,resulting in eretile dysfunction.关键词
高脂血症/睾酮/性激素结合蛋白/勃起功能障碍Key words
hyperlipidemias/testosterone/sex hormone-binding globulin/eretile dysfunction分类
医药卫生引用本文复制引用
董莹金,郑程,李远发,张成梅,申树林,梁季鸿..高脂血症模型大鼠血清总睾酮及性激素结合蛋白水平变化对勃起功能的影响[J].广西医科大学学报,2017,34(12):1699-1702,4.基金项目
广西科技计划项目重点研发计划项目(No.桂科AB16380216) （No.桂科AB16380216）
