广西医科大学学报2017，Vol.34Issue(12)：1710-1712,3.DOI:10.16190/j.cnki.45-1211/r.2017.12.008
miR-21及PDCD4在非小细胞肺癌的表达及其临床意义
The expressions of miR-21 and PDCD4 in non-small-cell lung cancer patients and its clinical significances
摘要
Abstract
Objective:To investigate the expressions of microscopic RNA-21 (miR-21) and programmed cell death factor 4 (PDCD4) in non-small-cell lung cancer (NSCLC) patients and its clinical significances.Methods:Lung cancer tissues and pericancer tissues were collected from 53 NSCLC patients.The expressions of miR-21 and PDCD4 were detected by fluorescent quantitative PCR (qPCR).Results:The expression of miR-21 in NSCLC tissues was significantly higher than that in the adjacent tissues,while the PDCD4 expression was lower (P＜0.01).Overexpression of miR-21 in NSCLC was associated with advanced clinical stage and lymph node metastasis,but low expression of PDCD4 was associated with lymph node metastasis and advanced TNM stage (P＜0.05).There was a negative correlation between the expressions of miR-21 and PDCD4 in NSCLC patients.Conclusion:Higher expression of miR-21 and lower expression of PDCD4 were closely related to the development of NSCLC.关键词
miR-21/程序性死亡因子4/实时荧光定量PCR/非小细胞肺癌Key words
miR-21/PDCD4/fluorescent quantitative PCR/non-small-cell lung cancer分类
医药卫生引用本文复制引用
卢锐,冼磊,莫俊贤,武国煜..miR-21及PDCD4在非小细胞肺癌的表达及其临床意义[J].广西医科大学学报,2017,34(12):1710-1712,3.基金项目
广西壮族自治区教育厅高校科研项目(No.YB2014060) （No.YB2014060）
广西医疗卫生适宜技术研究与开发项目(No.S2017011) （No.S2017011）
