广西医科大学学报2017，Vol.34Issue(12)：1765-1768,4.DOI:10.16190/j.cnki.45-1211/r.2017.12.024
艾司西酞普兰辅助治疗儿童神经性厌食症伴哮喘的临床疗效及安全性研究
Clinical efficacy and safety of escitalopram in the treatment of pediatric anorexia nervosa complicated with asthma
牟银莲 1陈一 2贺会利 1赵秀莲1
作者信息
- 1. 陕西省西安市阎良区人民医院儿科,西安 710089
- 2. 陕西省西安市儿童医院,西安 710043
- 折叠
摘要
Abstract
Objective:To investigate the clinical efficacy and safety of escitalopram in the treatment of pediatric anorexia nervosa (AN) complicated with asthma.Methods:62 AN children with asthma were divided into a control group and an observation group,with 31 cases in each group.The children in the control group received conventional therapy,and those in the observation group were treated as the control group with addition of escitalopram.The clinical efficacy,Hamilton anxiety scale (HAMA) score,Hamilton depression scale (HAMD) score,and AN symptom score were compared.Lung function and body mass index were observed as well.Results:The total response rate in the observation group was 93.55％,which was significantly higher than that in the control group (77.42％) (P＜ 0.05).After treatment,the forced expiratory volume in 1 second (FEV1),the ratio of FEV1 to forced vital capacity (FVC) and the peak expiratory flow (PEF) in the observation group were significantly higher than those in the control group,while the scores of HAMA,HAMD and AN symptoms were significantly lower (P＜ 0.05).After a follow-up of 3 months,a significant increase in body mass index was noted in the observation group,compared with the control group (P＜0.05).Conclusion:Escosipramine was safe and effective for the treatement of pediatric AN complicated with asthma.It could improve children's negative emotions,AN symptoms and lung function,and promote weight gain.关键词
神经性厌食症/哮喘/艾司西酞普兰/疗效/安全性Key words
anorexia nervosa/asthma/escitalopram/efficacy/safety分类
医药卫生引用本文复制引用
牟银莲,陈一,贺会利,赵秀莲..艾司西酞普兰辅助治疗儿童神经性厌食症伴哮喘的临床疗效及安全性研究[J].广西医科大学学报,2017,34(12):1765-1768,4.
