广西医科大学学报2018，Vol.35Issue(1)：26-29,4.DOI:10.16190/j.cnki.45-1211/r.2018.01.007
快通道麻醉对先天性心脏病手术患儿外周血炎症因子及微小核糖核酸-1的影响
Effect of fast-track anesthesia on inflammatory factors and miRNA-1 in peripheral blood in children with congenital heart disease undergoing cardiac surgery
摘要
Abstract
Objective:To investigate the effects of fast-track anesthesia (FTA) on inflammatory factors and miRNA-1 in peripheral blood in children with congenital heart disease undergoing cardiac surgery.Methods:A total of 120 children with congenital heart disease who undergoing cardiac surgery in our hospital from January 2015 to December 2016 were recruited and randomly divided into control group and FTA group,with 60 cases in each group.The children in the control group received general anesthesia,and those in the FTA group received FTA.The levels of tumor necrosis factor (TNF)-α,interleukin (IL)-6,C-reactive protein (CRP) and miRNA-1 in peripheral blood were measured before aortic cross-clamping (T0),15 min after cross clamping remission (CCR) (T1),30 min after CCR (T2),60 min after CCR (T3),and 180 min after CCR (T4).The relationship between the inflammatory factors and miRNA-1 was analyzed by Pearson correlation analysis.Results:Postoperative extubation time and CICU hospital days in FTA group were shorter than those in the control group (P＜ 0.05).Compared with T0,the levels of TNF-α,IL-6,CRP and miRNA-1 at T1 to T4 were increased in both groups,and the increase was more significant in FTA group (P＞ 0.05).The levels of TNF-α,IL-6 and CRP were positively correlated with miRNA-1 level (r=0.643,0.517,0.747;P＜0.05).Conclusion:FTA application in cardiac surgery could effectively reduce inflammatory factors and miRNA-1 levels in children with congenital heart disease.miRNA-1 might be used as a reliable marker for evaluating inflammatory degree after cardiac surgery.关键词
快通道麻醉/先天性心脏病/炎症因子/微小核糖核酸-1Key words
fast-track anesthesia/congenital heart disease/inflammatory factor/miRNA-1分类
医药卫生引用本文复制引用
莫伟波,黎必万,檀文好,陆彬堂,张碧莹..快通道麻醉对先天性心脏病手术患儿外周血炎症因子及微小核糖核酸-1的影响[J].广西医科大学学报,2018,35(1):26-29,4.基金项目
广西区卫计委自筹经费课题项目(No.Z2013736) （No.Z2013736）
钦州市科技术攻关项止(No.20164504) （No.20164504）
