广西医科大学学报2018，Vol.35Issue(1)：68-71,4.DOI:10.16190/j.cnki.45-1211/r.2018.01.018
支气管镜肺泡灌洗联合无创通气治疗重症肺炎合并呼吸衰竭的疗效观察
Clinical effect of bronchoalvoelar lavage combined with noninvasive ventilation on respiratory failure in patients with severe pneumonia
卢滨 1吴红科 1姚菲菲 1张翠翠1
作者信息
- 1. 河南省郑州人民医院呼吸内科,郑州450003
- 折叠
摘要
Abstract
Objective:To investigate the clinical effect of bronchoalvoelar lavage (BAL) combined with noninvasive ventilation on respiratory failure in severe pneumonia patients.Methods:80 severe pneumonia patients with respiratory failure treated in our hospital from January 2013 to June 2016 were enrolled and were randomly divided into an observation group and a control group,with 40 cases in each group.Patients in the control group received noninvasive positive-pressure ventilation,and those in the observation group were treated as the control group with addition of BAL.The total response rate,pulmonary function,blood gas and inflammatory factors levels were observed and compared.Results:The response rate in the observation group was significantly higher than that in the control group (P＜0.05).Compared with the control group,the PaO2,SaO2,FEF25％-75％,and DLCO were obviously increased,while the levels of high-mobility group box 1 protein (HMGB-1) and soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) in serum were decreased in the observation group (P＜ 0.05).Conclusion:BAL combined with noninvasive positive-pressure ventilation was effective in severe pneumonia patients with respiratory failure.It could improve pulmonary function and inhibit inflammatory response.关键词
重症肺炎/呼吸衰竭/无创通气/支气管镜肺泡灌洗Key words
severe pneumonia/respiratory failure/noninvasive ventilation/bronchoalvoelar lavage分类
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卢滨,吴红科,姚菲菲,张翠翠..支气管镜肺泡灌洗联合无创通气治疗重症肺炎合并呼吸衰竭的疗效观察[J].广西医科大学学报,2018,35(1):68-71,4.
