中医学报2018，Vol.33Issue(1)：42-46,5.DOI:10.16368/j.issn.1674-8999.2018.01.011
银杏叶提取物对慢性阻塞性肺疾病患者血栓前状态及气道重塑的作用
Effect of Extract of Ginkgo Biloba on Pre-thrombotic State and Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective:To investigate the effect of Ginkgo biloba extract on pre-thrombotic state and airway remodeling in patients with chronic obstructive pulmonary disease,and to provide reference for the popularization and application of Ginkgo biloba extract.Methods:500 patients with chronic obstructive pulmonary disease were randomly divided into control group and observation group,with 250 cases in each group.All patients in the control group were given conventional glucocorticoid,bronchodilator,antibiotics,expectorants and other supportive treatment as well as noninvasive positive pressure ventilation with ventilator;All patients in the observation group was treated with Ginkgo biloba extract in addition to that of the control group.Both groups were continuously treated for 3 courses,with 10 day as one course.The pulmonary function,pro-thrombotic state and airway remodeling between the two groups before and after treatment were examined and compared.Results:The forced expiratory volume in first second (FEV1) and FEV1/forced vital capacity (FVC) in observation group and control group were significantly higher than those before treatment (P ＜0.05).After treatment,FEV1 and FEV1 / FVC in the observation group were significantly higher than those in the control group (P ＜0.05).After treatment,the arterial oxygen saturation in observation group and control group were significantly increased,while the apnea hypopnea index was significantly decreased (P ＜ 0.05).After treatment,arterial oxygen saturation and apnea-hypopnea index in the observation group were significantly lower than those in the control group (P ＜ 0.05).D-dimer and FIB in observation group and control group were significantly lower than those before treatment (P ＜ 0.05);D-dimer and FIB in observation group were also significantly lower than those in control group after treatment (P ＜ 0.05).All patients were followed up for a period.The length of stay in hospital and outpatient visits of the observation group were (2.11 ± 1.03) days and (1.48 ±0.23) days respectively,which were significantly less than those of the control group,namely,(8.56-± 1.24) days and (3.45 ±0.22) days respectively (P ＜ 0.05).Conclusion:Ginkgo biloba extract is effective in treating for chronic obstructive pulmonary disease,which can improve the pre-thrombotic state,promote airway remodeling and is beneficially effective to improve patients'respiratory status,lung function and prognosis.关键词
银杏叶提取物/慢性阻塞性肺疾病/血栓前状态/气道重塑/肺功能/中西医结合Key words
Ginkgo biloba extract/chronic obstructive pulmonary disease/pre thrombotic state/airway remodeling/pulmonary function/Integrative medicine分类
医药卫生引用本文复制引用
高琳,陈玉宝..银杏叶提取物对慢性阻塞性肺疾病患者血栓前状态及气道重塑的作用[J].中医学报,2018,33(1):42-46,5.基金项目
国家科技支撑计划项目(2011BA04B03) （2011BA04B03）
