临床与实验病理学杂志2017，Vol.33Issue(10)：1074-1077,4.DOI:10.13315/j.cnki.cjcep.2017.10.003
胃癌组织中CTSD、HSP90α、EGFR的表达及临床意义
Expression of CTSD, HSP90α and EGFR in gastric cancer and their clinical significance
摘要
Abstract
Purpose To detect the expression of Cathepsin D(CTSD),heat shock protein 90α (HSP90α) and epidermal growth factor receptor (EGFR) in gastric cancer (GC) tissues and to analyze the association of their expression levels and clinical pathological features of GC,the role of CTSD,HSP90α,EGFR in the carcinogenesis,progression,invasion and metastasis of GC.Methods The expression of CTSD,HSP90α and EGFR in normal gastric mucosa,dysplasia adjacent to carcinoma,GC tissues and lymph node metastasis was measured by immunohistochemistry (IHC) and in situ hybridization (ISH).Results In 110 cases of normal gastric mucosa,83 cases of dysplasia adjacent to carcinoma,110 cases of GC and 78 cases of the lymph node metastasis,the positive rate of CTSD,HSP90α,EGFR protein was 0,18.7％,80.91％ and 92.31％,0.9％,15.66％,75.45％ and 89.74％,0,12.05％,69.09％ and 84.62％,respectively.Correlation analysis showed that the expression CTSD,HSP90α and EGFR in GC tissues was positively correlated (rs =0.853,P ＜ 0.05,rs =0.639,P＜0.05,rs =0.734,P＜0.05).Expression of CTSD,HSP90α and EGFR in GC was correlated with the degree of tumor differentiation,invasive depth,number of lymph node metastasis and TNM stages (P ＜ 0.05).There was no significant correlation with the patient's age,sex,tumor size (P ＞0.05).Conclusion CTSD,HSP90α and EGFR may be associated with malignant behavior,development and invasion and metastasis of GC.关键词
胃肿瘤/CTSD/HSP90α/EGFR/临床病理特征Key words
gastric neoplasms/CTSD/HSP90α/EGFR/clinicopathologic features分类
医药卫生引用本文复制引用
李禹,程爱兰..胃癌组织中CTSD、HSP90α、EGFR的表达及临床意义[J].临床与实验病理学杂志,2017,33(10):1074-1077,4.基金项目
国家自然科学基金(81372894、81072198)、湖南省教育厅重点项目(10A104) （81372894、81072198）
