临床与实验病理学杂志2017，Vol.33Issue(10)：1078-1081,4.DOI:10.13315/j.cnki.cjcep.2017.10.004
胃癌组织中eIF-4E和p4EBP-1蛋白表达的临床意义
Clinical significance of expression of eIF-4E and p-4EBP-1 protein in the gastric carcinoma
摘要
Abstract
Purpose To study the expression of eIF-4E and p-4EBP-1 and its clinical significance in the gastric carcinoma.Methods Expression of eIF-4E and p-4EBP-1 was detected in tissue array including 168 cases of gastric carcinoma and 52 cases of peri-cancer tissues by immunohistochemical SP method.Results The positive expression of eIF-4E and p-4EBP-1 in the gastric carcinoma was significantly higher than that of peri-cancer tissues (P =0.001,P =0.000).There was significantly higher expression of eIF-4E and p-4EBP-1 with lymph node metastases than without lymph node metastases in the gastric carcinoma (P =0.025,P =0.001).Also,there was significantly higher expression of eIF-4E and p-4EBP-1 with clinical stages Ⅲ + Ⅳ than that of stages Ⅰ + Ⅱ (P =0.001,P=0.049).In addition,there was a significantly positive correlation between the expression of eIF-4E and p-4EBP-1 in the gastric carcinoma (r =0.432,P ＜ 0.01).The overall survival rates for patients with negative expression of eIF-4E protein was higher than that with positive expression (P =0.012).Conclusion The abnormal co-expression of eIF-4E and p-4EBP-1 may be related to the tumorgenesis,development,metastasis and invasion of gastric carcinoma,and eIF-4E and p-4EBP-1 may act as the new molecular targets for the therapy and diagnosis of gastric carcinoma.关键词
胃肿瘤/eIF-4E/p-4EBP-1Key words
gastric neoplasms/eIF-4E/p-4EBP-1分类
医药卫生引用本文复制引用
郑军,张春燕,张毅强,马丽莉,裴晋红..胃癌组织中eIF-4E和p4EBP-1蛋白表达的临床意义[J].临床与实验病理学杂志,2017,33(10):1078-1081,4.基金项目
长治医学院科技创新项目(CX201502) （CX201502）
