临床与实验病理学杂志2017，Vol.33Issue(10)：1092-1096,5.DOI:10.13315/j.cnki.cjcep.2017.10.007
ALK阳性非小细胞肺癌72例临床病理分析
Non-small cell lung cancer with EML4-ALK positive expression: a clinicopathological analysis of 72 cases
曹培龙 1王凯 1王鸿雁 1张冠军 1王春宝 1蒋娜 1赵荧1
作者信息
- 1. 西安交通大学第一附属医院病理科,西安710061
- 折叠
摘要
Abstract
Purpose To investigate the frequency of anaplastic lymphoma kinase (ALK) expression in non-small cell lung cancer (NSCLC) patients and its correlation with the clinicopathologic features.Methods 1 047 cases of non-small cell lung cancer diagnosed by pathological examination were enrolled in this study.The status of ALK was detected by Ventana anti ALK reagent and IHC staining,and the clinical characteristics and pathological features of ALK gene were analyzed.Results Among 1 047 patients with non-small cell lung cancer,there are 72 cases with positive ALK (6.88％).These cases included 70 cases of adenocrcinoms and 2 adenosquamous carcinomas,with 40 males and 32 females,or 37 smokers and 35 non-smokers.The median age was 56 years and the mean age was 55.60 years.Histopathologically,43 cases were solid predominant adnocarcinomas,16 cases were acinar predominant adenocarcinomas,and 13 cases were papillary predominant adenocarcinomas.None were lepidic predominant adenocarcinomas.Conclusion ALK gene fusion lung cancer is a new molecular subtype of nonsmall cell lung cancer.It has unique clinical feature and pathological morphology.Ventana anti ALK reagent and IHC staining method are the first choice for the test of ALK positive non-small cell lung cancer,which has important significance to improve the detection rate and individual treatment for this type of lung cancer.关键词
肺肿瘤/非小细胞肺癌/间变性淋巴瘤激酶/免疫组织化学Key words
lung neoplasms/non-small cell lung cancer/anaplastic lymphoma kinase/immunohistochemistry分类
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曹培龙,王凯,王鸿雁,张冠军,王春宝,蒋娜,赵荧..ALK阳性非小细胞肺癌72例临床病理分析[J].临床与实验病理学杂志,2017,33(10):1092-1096,5.
