临床与实验病理学杂志2017，Vol.33Issue(10)：1097-1100,4.DOI:10.13315/j.cnki.cjcep.2017.10.008
嗜酸细胞型甲状腺髓样癌3例并文献复习
Oncocytic variant of medullary thyroid carcinoma: 3 cases report with review of literatures
刘栋 1罗丕福 1尹自长 1吴涛 1侯晓涛 1李晶 1周辉蓉 1梁小曼2
作者信息
- 1. 广州金域医学检验中心病理科,广州510330
- 2. 中山大学附属肿瘤医院病理科,广州510060
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathologic features and differential diagnosis of oncocytic variant of medullary thyroid carcinoma (MTC).Methods Morphological,immunohistochemical findings on 3 oncocytic variant of MTC cases and electron microscopic findings on 2 of these 3 cases were studied,with review of the relevant literatures.Results The cytoplasm was abundant,eosinophilic and granular with defined margins.The nuclei were enlarged,round to oval.Prominent nucleoli were identified in some cells.Tumor cells formed sheets,trabeculae or follicles with infiltrative pattern.Immunohistochemically,thyroglobulin (TG) was negative in all 3 cases.Calcitonin was positive in 2 cases and negative in 1 case.Ultrastructurally,a large number of mitochondria and various neuroendocrine granules were found in the 2nd and 3rd cases.Conclusion Oncocytic variant of MTC is very rare with variable histopathologic appearances.It should be considered in diagnosing oncocytic lesions of thyroid.A definite diagnosis can be rendered based on comprehensive findings of the immunohistochemistry,serology study and electron microscopy.It needs to avoid misdiagnosis and missed diagnosis.关键词
甲状腺肿瘤/髓样癌/嗜酸细胞型Key words
thyroid neoplasms/medullary carcinoma/oncocytic分类
医药卫生引用本文复制引用
刘栋,罗丕福,尹自长,吴涛,侯晓涛,李晶,周辉蓉,梁小曼..嗜酸细胞型甲状腺髓样癌3例并文献复习[J].临床与实验病理学杂志,2017,33(10):1097-1100,4.
