中国临床保健杂志2017，Vol.20Issue(6)：659-661,3.DOI:10.3969/J.issn.1672-6790.2017.06.010
肿瘤坏死因子-α与转化生长因子-β1和癌症相关性乏力的关系
The relationship between cancer-related weakness and TNF-αand TGF-β1
摘要
Abstract
Objective To investigate the relationship between cancer-related weakness and TNF-α and TGF-β1.Methods A total of 92 cancer patients with light and mediumly weak were enrolled in observation group,and 92 cases of healthy physical examination were enrolled in control group.The serum TNF-αand TGF-β1were detected by using flow cytometry.Results Before treatment,the serum TNF-αlevels of observation group was(27.35 ±12.08) ng/L,which was significantly higher than that of control group(12.04 ±5.44)ng/L(t=11.080,P<0.001).And af-ter treatment,the TNF-αof observation group reduced to(18.57 ±10.32)ng/L(t=5.369,P<0.001).Before treat-ment,the serum TNF-β1levels of observation group was(39.26 ±10.65)ng/L,which was significantly higher than that of control group(16.53 ±6.37)ng/L(t=17.570,P<0.001),which was reduced to(25.98 ±7.87)ng/L(t=8.952,P<0.001)after treatment.Conclusion The pathogenesis of cancer-related weakness may be due to the in-crease of serum TNF-αand TGF-β1.关键词
肺肿瘤/虚弱/肿瘤坏死因子α/转化生长因子β1Key words
Lung neoplasms/Asthenia/Tumor necrosis factor-alpha/Transforming growth factor beta1分类
医药卫生引用本文复制引用
苏树伟,崔海银,路晓波,岳韦名,李林..肿瘤坏死因子-α与转化生长因子-β1和癌症相关性乏力的关系[J].中国临床保健杂志,2017,20(6):659-661,3.基金项目
山东省医药卫生科技发展计划项目(2014WS0324) （2014WS0324）
