中国临床保健杂志2017，Vol.20Issue(6)：676-678,3.DOI:10.3969/J.issn.1672-6790.2017.06.014
氟伏沙明对癌症后抑郁患者血清褪黑素的影响
Effects of fluphenazine on serum melatonin of patients with post-cancer depression
摘要
Abstract
Objective To investigate the effects of fluvoxamine on the depression and serum melatonin of pa-tients with post-cancer.Methods 100 patients with post-cancer depression were selected as the study subjects and ran-domly divided into two groups.The control group was given routine anti-cancer treatment and the observation group was given oral administration of fluorophoramine based on the control group.All patients were treated for 4 weeks.After treat-ment of 1 week,2 weeks and 4 weeks,the depression was assessed by Hamilton Depression Scale(HAMD)and the anx-iety was assessed using the Hamilton Anxiety Scale(HAMA).The living daily ability was assessed by living daily ability scale(ADL)and serum melatonin was detected by reflective immunoassay.Results After treatment,the HAMD and HAMA score of observation group were significantly reduced(P<0.05).HAMD and HAMA score of observation group at 4 week were significantly lower than those of control group[(14.15 ±2.62)VS.(22.53 ±3.18),(12.07 ±2.52) VS.(21.58 ±4.06),P<0.05).After treatment,the ADL score of observation group significantly increased gradually (P<0.05),ADL score of observation group at 4 week was significantly higher than that of control group[(78.53 ± 12.76)VS.(61.03 ±12.08),P<0.05].After treatment,serum melatonin levels of two groups were both significantly increased(P<0.05),and the observation group was significantly higher than the control group[(52.89 ±7.35)ng/L VS.(40.46 ±3.76)ng/L,P<0.05].Conclusion Fluvoxamine could effectively treat post-cancer depression,improve the depressive symptoms.The mechanism may be related to its regulation of serum melatonin.关键词
肿瘤/抑郁/褪黑激素/氟伏沙明Key words
Neoplasms/Depression/Melatonin/Fluvoxamine分类
医药卫生引用本文复制引用
杨清,杨绍峰,张璐璐,毕晓伟,张艳,王梅,史风磊..氟伏沙明对癌症后抑郁患者血清褪黑素的影响[J].中国临床保健杂志,2017,20(6):676-678,3.基金项目
山东省自然科学基金项目(ZR2015HM049) （ZR2015HM049）
