中国临床保健杂志2018，Vol.21Issue(1)：51-54,4.DOI:10.3969/J.issn.1672-6790.2018.01.015
丹参川芎嗪联合替罗非班对急性ST段抬高型心肌梗死患者冠脉介入术后视黄醇结合蛋白4的影响
The Effficacy to retinol binding protein of salvia-chuanxiong combined with tirofiban in patients with acute ST-eleva-tion myocardial infarction receiving percutaneous coronary intervention
摘要
Abstract
Objective To investigate the effect of Salvia miltiorrhiza Ligustrazine combined with half dose tiro-fiban on the postoperative serum retinol binding protein 4(RBP4)level and clinical ischemic events in acute ST eleva-tion myocardial infarction(STEMI)patients who recevied percutaneous coronary intervention(PCI).Methods Strati-fied randomization method was adpoted to divede 130 cases underwent PCI STEMI into two groups,60 cases in the con-trol group after PCI treated with conventional treatment,70 cases in observation group were given the other half dose tiro-fiban treatment 48h combined with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection 7d.The postoperative related indexes(7d,RBP4 and glomerular filtration rate,troponin T)and clinical ischemic events(ischemia and hemor-rhage events,coronary TIMI blood flow)were evaluated.Results The mean value of serum RBP4 and CTnT in the ob-servation group decreased and GFR increased compared with the control group on the 7 day after operation,Ischemic and hemorrhagic events did not show significant difference for half a year.Conclusion The use of Danshen Ligustrazine combined with half dose tirofiban in patients with PCI can reduce the level of RBP 4 in patients with STEMI,improve the renal function and myocardial ischemia without increasing the risk of bleeding.关键词
心肌梗死/心肌血管重建术/视黄醇结合蛋白质类/丹参/川芎/替罗非班Key words
Myocardial infarction/Myocardial revascularization/Retinol-binding proteins/Sakia miltiorrhiza/Li-gusticm Chuanxiong/Tirofiban分类
医药卫生引用本文复制引用
周琳,李嘉俊,任继刚,王建,杨靖,廖雪艳..丹参川芎嗪联合替罗非班对急性ST段抬高型心肌梗死患者冠脉介入术后视黄醇结合蛋白4的影响[J].中国临床保健杂志,2018,21(1):51-54,4.基金项目
四川省科技支撑计划(2013SZ0082) （2013SZ0082）
