中国临床保健杂志2018，Vol.21Issue(1)：58-61,4.DOI:10.3969/J.issn.1672-6790.2018.01.017
多巴丝肼联合米氮平治疗帕金森患者的效果及其对心理状态的影响
Benserazide combined with mirtazapine in the treatment of patients with parkinson effect and influence on the psychological state
摘要
Abstract
Objective To investigate the application value of benserazide combined with mirtazapine in the treatment of parkinson′s disease.Methods 94 patients with parkinson′s disease were selected as the research object, and were randomly divided into the control group of 47 cases and the observation group of 47 cases,Two groups of pa-tients were given psychological counseling,exercise training,symptomatic treatment of complications,the control group was treated with levodopa and benserazide hydrochloride,the observation group in the control group based on the com-bined treatment of mirtazapine,The changes of parkinson disease unified score scale(UPDRS),Hamilton Anxiety Scale (HAMA)and Hamilton Depression Scale(HAMD)before and after treatment and adverse reactions during treatment were observed in the two groups.Results there was no significant difference in UPDRS scores between the two groups before treatment,but decreased after treatment.The scores of UPDRS I,UPDRS II and UPDRS III scores in the observa-tion group were significantly lower than those in the control group,with statistical difference(P<0.05).There was no significant difference in psychological status between the two groups before treatment,and improved after treatment.The scores of HAMD and HAMA in the observation group were significantly lower than those in the control group,with statis-tical difference(P<0.05).The incidence of adverse reactions in the observation group was 14.89%compared with 8. 51% in the control group,the difference was not statistically significant(P>0.05),there were no serious adverse reac-tions in the two groups.Conclusion Levodopa and benserazide hydrochloride combined with mirtazapine in the treat-ment of Parkinson′s disease has better curative effect and high safety,and can effectively improve the psychological sta-tus of patients.关键词
帕金森病/苄丝肼/左旋多巴/米氮平/治疗结果Key words
Parkinson disease/Benserazide/Levodopa/Mirtazapine/Treatment outcome分类
医药卫生引用本文复制引用
陈美红,邱伟文..多巴丝肼联合米氮平治疗帕金森患者的效果及其对心理状态的影响[J].中国临床保健杂志,2018,21(1):58-61,4.基金项目
浙江省医药卫生一般研究计划(2015KYB451) （2015KYB451）
