山西农业大学学报（自然科学版）2018，Vol.38Issue(1)：38-44,7.DOI:10.13842/j.cnki.issn1671-8151.201708025
新型胆固醇腙类衍生物的合成及其杀虫活性初探
Synthesis and insecticidal activity of novel cholesterol-hydrazone derivatives
摘要
Abstract
[Objective]This research aimed to find novel natural-product-based pesticidal agents with high bioactivity.[Meth-ods]Two series of novel hydrazone derivatives were synthesized using cholesterol as the lead compound by chemical derivat-ization method and their structures were well characterized by 1H NMR and IR et al.Meanwhile,insecticidal activity was al-so preliminarily tested against the pre-third-instar larvae of Mythimna separata(Walker)in vivo by leaf disk at the concen-tration of 1 g·L -1.[Results]1H NMR and IR showed that all derivatives were target compound.In general,all derivatives displayed better insecticidal activity than their precursor cholesterol.In comparison with toosendanin,the positive control a-gent,most compounds showed more promising activity,especially compound 3 d exhibited the best potent insecticidal activi-ty with the final mortality rate of 55.2%.In the meantime,the data indicated that the most of derivatives showed delayed insecticidal activity.Namely,the lethal and teratogenic effects were mainly concentrated in the pupa and adult stages.[Con-clusion]The result of this study indicated that the introduction of hydrazone structure to cholesterol could be useful to im-prove insecticidal activity and these compounds may be developed as novel potent natural-product-based insecticides.关键词
胆固醇/化学衍生/东方粘虫/杀虫活性Key words
Cholesterol/Chemical derivatization/Mythimna separata(Walker)/Insecticidal activity分类
农业科技引用本文复制引用
杨春,郅晓燕,王熠,曹挥..新型胆固醇腙类衍生物的合成及其杀虫活性初探[J].山西农业大学学报（自然科学版）,2018,38(1):38-44,7.基金项目
国家自然科学基金(31700300,21702129) （31700300,21702129）
山西农业大学科技创新基金(2016YJ10,2016YJ09) （2016YJ10,2016YJ09）
