实用妇产科杂志2018，Vol.34Issue(1)：42-45,4.
2178对自然流产史夫妇染色体分析
Karyotype Analysis of 2178 Couples with Spontaneous Abortions
摘要
Abstract
Objective:To analyze the types and distribution characteristics of abnormal karyotypes of peripheral blood in couples with spontaneous abortion.Methods:The chromosome karyotype analysis of peripheral lymphocytes in 2178 couples with spontaneous abortion was performed.The incidence,types and sex distribution were analyzed and compared.Results:In all,abnormal karyotypes were found in 539 cases (12.37％) (266 males and 273 females).The abnormalities in chromosome structure were detected in 87 cases.The most frequent type was reciprocal translocation (n =58,66.7％),among which 27 cases were the abnormal karyotype which was first reported in the world,following by Robertson translocation(n =13),inversion (n =6)and 10 cases of other abnormal karyotypes such as insertion and deletion.The abnormalities in number of chromosome were detected in 8 cases,including mark chromosome(n =2),1 cases of XYY,and 5 cases of mosaic X chromosome aneuploidy.Among the 444 cases of chromosome polymorphic,satellite variation on D and G chromosome was the most common (n =271,61.04％).Conclusions:The chromosomal abnormalities in male and female of the couples with spontaneous abortion have been observed.There is no significant difference between male and female,and reciprocal translocation is the most frequent chromosomal abnormalities.In addition,chromosome polymorphism had a higher incidence of couples with spontaneous abortion,it is necessary to undergo peripheral blood karyotype analysis at the mean time.It is contribute to analysis and diagnosis of the cause of disease,and provides the basis for clinical consultation and reproductive intervention.关键词
自然流产/核型分析/染色体异常/多态性改变Key words
Spontaneous abortion/Karyotyping/Chromosomal abnormalities/Polymorphism分类
医药卫生引用本文复制引用
王瑾,陶靖,鲁婷,金华,高青,蔡艳..2178对自然流产史夫妇染色体分析[J].实用妇产科杂志,2018,34(1):42-45,4.基金项目
山东省自然科学基金(编号:ZR2014HP047) （编号:ZR2014HP047）
山东省济南市科学技术发展计划项目(编号:201201054) （编号:201201054）
济南市卫生和计划生育委员会科技发展计划项目(编号:2017-2-05) （编号:2017-2-05）
