中国当代儿科杂志2018，Vol.20Issue(2)：106-111,6.DOI:10.7499/j.issn.1008-8830.2018.02.005
血管活性药物评分与儿童脓毒性休克预后的关系
Association between vasoactive-inotropic score and prognosis in children with septic shock
秦嫣然 1刘成军 1许峰 1李静 1熊小雨1
作者信息
- 1. 重庆医科大学附属儿童医院重症医学科/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆 400014
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摘要
Abstract
Objective To investigate the association between vasoactive-inotropic score (VIS) and prognosis in children with septic shock. Methods A total of 117 children with decompensated septic shock who received the treatment with vasoactive agents were enrolled. According to their prognosis, they were divided into death group with 41 children and survival group with 76 children. With the maximum VIS within the first 24 hours (24hVIS max) as the cut-off value (29.5), the children were divided into low VIS group with 78 children and high VIS group with 39 children. The 24hVIS max and the mean VIS within the first 24 hours (24hVIS mean) were calculated for all children. A receiver operating characteristic (ROC) curve analysis was performed for the association between VIS and the prognosis of septic shock. Results Compared with the survival group, the death group had significantly higher 24hVIS max, 24hVIS mean, PRISM Ⅲ score, and level of lactate before the use of vasoactive agents and after 24 hours of use (P<0.05). 24hVIS max, 24hVIS mean, PRISM Ⅲ score, level of lactate before the use of vasoactive agents and after 24 hours of use, and 24-hour pH had a certain value in predicting the prognosis of septic shock, but 24hVIS max had the largest area under the ROC curve. Compared with the low VIS group, the high VIS group had significantly higher number of deaths, PRISM Ⅲ score, and level of lactate before treatment and after 24 hours of treatment (P<0.05). Conclusions VIS is associated with the mortality of children with septic shock, and the severity and mortality of patients increase with the increase in VIS.关键词
脓毒性休克/血管活性药物评分/PRISMⅢ评分/儿童Key words
Septic shock/Vasoactive-inotropic score/PRISM Ⅲ score/Child引用本文复制引用
秦嫣然,刘成军,许峰,李静,熊小雨..血管活性药物评分与儿童脓毒性休克预后的关系[J].中国当代儿科杂志,2018,20(2):106-111,6.
