中国动物传染病学报2018，Vol.26Issue(1)：81-88,8.
MAVS介导的抗病毒天然免疫信号通路的调控
THE REGULATION OF MAVS-MEDIATED ANTIVIRAL INNATE IMMUNITY
摘要
Abstract
As the first barrier of immune defense towards invading pathogens, the signaling pathway of the innate immunity plays an important role in antiviral response. The most important cytoplasmic pathogen recognition receptors are retinoic acid-inducible gene 1 and differentiation-associated protein 5. They possess the same downstream adaptor mitochondrial antiviral-signaling protein (MAVS). MAVS functions as the central molecular tool in innate immunity signaling pathway. MAVS-mediated signaling pathway is the important antiviral mechanism. However, viruses obtain a series of anti-MAVS mechanisms in the long-term coexistence status. Furthermore, cells in the resting state possess a number of MAVS regulation mechanisms to avoid excessive immune response. The delicate regulation of MAVS is critical for cell function and antiviral response. This review briefly introduces the structure and function as well as transcriptional and translational regulation mechanisms of MAVS. Furthermore, the mechanisms how viruses "fight back" MAVS-mediate innate immunity are elaborated. Understanding the regulation mechanism of MAVS may provide new insights into therapeutic strategies for the immunity regulation and virus infection.关键词
天然免疫/线粒体抗病毒信号蛋白/病原体/宿主Key words
Innate immunity/mitochondrial antiviral-signaling protein/pathogen/host分类
农业科技引用本文复制引用
郑航,孙英杰,张频,丁铲..MAVS介导的抗病毒天然免疫信号通路的调控[J].中国动物传染病学报,2018,26(1):81-88,8.基金项目
国家自然科学基金重点项目(31530074) （31530074）
国家自然科学基金面上项目(31372421) （31372421）
国家自然科学基金青年基金(31400144) （31400144）
