中国药房2017，Vol.28Issue(30)：4229-4232,4.DOI:10.6039/j.issn.1001-0408.2017.30.15
复方黄柏液联合化学药治疗溃疡性结肠炎的Meta分析
Meta-analysis of Compound Huangbo Liquid Combined with Chemical Medicine in the Treatment of Ulcerative Colitis
摘要
Abstract
OBJECTIVE:To systematically evaluate the clinical efficacy and safety of Compound Huangbo liquid combined with chemical medicine in the treatment of ulcerative colitis (UC),and to provide evidence-based reference.METHODS:Re trieved from CBM,Wanfang Database,VIP,CJFD,PubMed,EMBase and Cochrane Library,randomized controlled trials(RCTs) about Compound Huangbo liquid combined with chemical medicine (trial group) vs.chemical medicine alone (control group) in the treatment of UC were collected.Meta-analysis was performed by using Rev Man 5.3 statistical sofetware after literature scanning,data extraction and quality evaluation according to Cochrane reviewer's handbook 5.1.0.RESULTS:A total of 8 RCTs were included,involving 737 patients.The results of Meta-analysis showed that,response rate of trial group was significantly higher than that of control group,with statistical significance [OR=4.69,95 ％ CI(3.00,7.34),P＜0.001];there was no statistical significance in the incidence of ADR between 2 groups [OR=0.94,95 ％ CI (0.48,1.84),P=0.86].CONCLUSIONS:Compound Huangbo liquid combined with chemical medicine is better than chemical medicine alone for UC,and both have similar safety.关键词
复方黄柏液/溃疡性结肠炎/Meta分析/疗效/安全性Key words
Compound Huangbo liquid/Ulcertive colitis/Meta-analysis/Therapeutic efficacy/Safety分类
医药卫生引用本文复制引用
李辉标,陈新林,陈慕媛,丘振文,李得堂,唐洪梅..复方黄柏液联合化学药治疗溃疡性结肠炎的Meta分析[J].中国药房,2017,28(30):4229-4232,4.基金项目
国家自然科学基金资助项目(No.81403296) （No.81403296）
