中国药房2017，Vol.28Issue(30)：4238-4241,4.DOI:10.6039/j.issn.1001-0408.2017.30.17
伐昔洛韦对比阿昔洛韦治疗带状疱疹疗效和安全性的Meta分析
Meta-analysis of Therapeutic Efficacy and Safety of Valaciclovir versus Acyclovir in the Treatment of Herpes Zoster
摘要
Abstract
OBJECTIVE:To evaluate therapeutic efficacy and safety of valaciclovir versus acyclovir in the treatment of herpes zoster,and to provide evidence-based reference in clinic.METHODS:Retrieved from PubMed,Medline,CJFD,VIP and Wanfang Database,randomized controlled trials (RCTs) about valaciclovir (trial group) versus acyclovir (control group) in the treatment of herpes zoster were included.The data was analyzed statistically by using Rev Man 5.3 software after data extraction and quality evaluation by Cochrane systematic reviewer manual 5.1.0.RESULTS:A total of 12 RCTs were included,involving 1 059 patients.The result of Meta-analysis showed that:total response rate [OR =4.64,95 ％ CI (2.99,7.20),P＜ 0.001] and cure rate [OR =2.93,95％CI(2.13,4.03),P＜0.001] of trial group were significantly higher than those of control group;the incidence of postherpetic neuralgia in trial group [OR=0.39,95％CI(0.22,0.69),P=0.001] was significantly lower than control group,with statistical significance.There was no statistical significance in the incidence of ADR between 2 groups [OR=0.79,95％CI(0.49,1.29),P=0.35].CONCLUSIONS:Therapeutic efficacy of valaciclovir is better than that of acyclovir in the treatment of herpes zoster,can significantly reduce the incidence of postherpetic neuralgia.Both have similar safety.关键词
伐昔洛韦/阿昔洛韦/带状疱疹/Meta分析/疗效/安全性Key words
Valaciclovir/Acyclovir/Herpes zoster/Meta-analysis/Therapeutic efficacy/Safety分类
医药卫生引用本文复制引用
王莉,问亭亭,冀秀萍,马骋宇,樊卓..伐昔洛韦对比阿昔洛韦治疗带状疱疹疗效和安全性的Meta分析[J].中国药房,2017,28(30):4238-4241,4.基金项目
陕西省科技技术研究发展计划项目(No.2015SF080) （No.2015SF080）
陕西省教育厅科学研究项目(No.14JK1628) （No.14JK1628）
