中国医科大学学报2017，Vol.46Issue(10)：903-908,912,7.DOI:10.12007/j.issn.0258-4646.2017.10.010
hMOF蛋白在食管癌中的表达及其与放射治疗预后的关系
Expression of hMOF in Esophageal Cancer and Its Correlation with Radiotherapy Prognosis
摘要
Abstract
Objective To examine human males absent on the first (hMOF) protein expression in patients with esophageal cancer and explore its correlation with radiotherapy prognosis.Methods Prior to radiotherapy,hMOF protein expression levels were examined using immunohistochemistry,in 13 pairs of esophageal cancer tissues and adjacent,non-tumorous,esophageal tissues,as well as in 90 esophageal cancer biopsy tissues.The hMOF protein expression level was classified into a high-expression group and a low-expression group,based on immunohistochemical staining scores.The correlation between these groups and radiotherapy prognosis was analyzed.Results Both esophageal cancer tissues and adjacent,non-tumorous,esophageal tissues displayed hMOF protein expression,although a significantly higher level of hMOF expression was found in esophageal cancer tissues (P ＜ 0.05).Survival analysis showed that hMOF protein expression and chemotherapy were independent prognostic factors.The 1-,3-,and 5-year survival rates of patients receiving concurrent chemoradiotherapy were higher than the survival rates in patients receiving sequential chemotherapy or radiotherapy alone.The survival rate after radiotherapy was lower in the high hMOF expression group than in the low-expression group.Conclusion hMOF protein expression may be involved in the development and tumorigenesis of esophageal cancer.In patients with esophageal cancer,hMOF could be used as a new radiotherapy prognostic marker.关键词
人类第一雄性缺失蛋白/食管癌/放射治疗预后/免疫组化Key words
human males absent on the first protein/esophageal cancer/radiotherapy prognosis/immunohistochemistry分类
医药卫生引用本文复制引用
唐玲荣,李光,党军,纪天龙,姚雷..hMOF蛋白在食管癌中的表达及其与放射治疗预后的关系[J].中国医科大学学报,2017,46(10):903-908,912,7.基金项目
沈阳市科学技术计划(F14-158-9-33) （F14-158-9-33）
