中国医科大学学报2017，Vol.46Issue(11)：970-975,6.DOI:10.12007/j.issn.0258-4646.2017.11.003
结直肠癌中LAMP2a编码蛋白的表达及临床病理意义
Expression and Clinicopathological Significance of LAMP2a in Colorectal Cancer
摘要
Abstract
Objective To investigate the clinicopathological and prognostic significance of lysosome-associated membrane protein-2a (LAMP2a) expression in the development of colorectal cancer.Methods Immunohistochemistry was performed to detect the LAMP2a expression in colorectal cancer,normal mucosa,and adenoma tissues.Results LAMP2a expression in colorectal cancer and adenoma was higher than that in normal mucosa (P ＜ 0.05).Further,LAMP2a expression in colorectal cancer was negatively correlated with TNM staging and lymph node metastasis (P ＜ 0.05);however,the invasion and liver metastasis,depth of invasion and differentiation had no correlation with the lymph node (P ＞ 0.05).Kaplan-Meier analysis showed that LAMP2a expression in colorectal cancer is not significantly correlated with good prognosis (P ＞ 0.05).Univariate survival analysis showed that lymphatic invasion,vascular invasion,lymph node metastasis,TNM stage,liver metastasis,distant metastasis,and differentiation were correlated with poor prognosis of colorectal cancer (P ＜ 0.05).The Cox proportional hazards regression model showed that the depth of invasion and distant metastasis were important factors affecting the survival period of patients with colorectal cancer (P ＜ 0.05).Conclusion LAMP2a may play a role in the carcinogenesis and progression of colorectal cancer,and may be used as a molecular marker for the biological behavior of colorectal cancer.关键词
结直肠癌/溶酶体相关膜蛋白2a/肿瘤发生/演进/预后Key words
colorectal cancer/lysosome associated membrane protein-2a/carcinogenesis/progression/prognosis分类
医药卫生引用本文复制引用
时帅,窦建华,唐光波,赵爽,聂勇战,郑华川..结直肠癌中LAMP2a编码蛋白的表达及临床病理意义[J].中国医科大学学报,2017,46(11):970-975,6.基金项目
国家自然科学基金(81472544 （）
81672700) （）
辽宁省科技攻关项目(2015408001) （2015408001）
辽宁省百千万人才项目(2015408001) （2015408001）
