摘要
Abstract
Objective To analyze the etiology, clinical characteristics and prognosis of ophthalmoplegia associated with vascular diseases. Methods It was a retrospective case series study. The clinical data of patients with ophthalmoplegia associated with vascular diseases who received consultation in Beijing Tongren hospital, Capital Medical University from December 2012 to July 2016 were collected, including the clinical manifestations, physical examination, past history of disease, laboratory tests and imaging examinations. The patients were followed up and the remission time of ophthalmoplegia were recorded. The etiology, clinical characteristics and prognosis of ophthalmoplegia were analyzed. Results A total of 126 patients were enrolled into this study. The results were shown as below: (1) Microvascular ischemic (MVI) disease was the most common cause of ophthalmoplegia associated with vascular diseases, accounting for 81.7 percent, followed by brainstem infarction (13.5%), and aneurysm, ophthalmoplegia migraine (OM), cavernous sinus venous fistula were rare causes. The major risk factors of MVI and brainstem infarction were hypertension, hyperlipidemia, smoking, diabetes and alcoholism. (2)The oculomotor nerve was the most common involved nerve(57.3%) by MVI disease of ocular motor nerves,followed by abducens nerve (26.2%), trochlear nerve(16.5%). The ophthalmoplegia caused by brainstem infarction involved the oculomotor nucleus most (70.6%),followed by medial longitudinal fasciculus (17.6%). (3)About 49.5% MVI patients might be associated with headache or periorbital pain. (4)The symptoms of 88.5% MVI could relieve, of which about 50% within 3 months and 75% within 6 months. Conclusion MVI disease is the most common cause of ophthalmoplegia associated with vascular diseases. Hypertension, hyperlipidemia, smoking, diabetes, alcoholism are major risk factors of MVI. Most patients of MVI disease could relieve in 6 months after treatment.关键词
血管病/眼肌麻痹/微血管缺血性病变/脑干梗死/预后Key words
Vascular disease/Ophthalmoplegia/Microvascular ischemic disease/Brainstem infarction/Prognosis
