中国卒中杂志2018，Vol.13Issue(1)：54-57,4.DOI:10.3969/j.issn.1673-5765.2018.01.011
丁苯酞注射液对急性大面积脑梗死体积及基质金属蛋白酶-9的影响
Effect of Butylphthalide Injection on Volume of Acute Massive Cerebral Infarction and the Matrix Metalloproteinase-9
王喜丰 1李刚 1付群芳 1俞小梅 1张静 1汪敏 1肖瑶 1沈伟1
作者信息
- 1. 443000 武汉 华中科技大学同济医学院附属普爱医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the effect of butylphthalide injection on matrix metalloproteinase-9 and the volume of acute massive cerebral infarction. Methods A total of 58 cases with acute massive cerebral infarction were randomly divided into control group (n=29) and treatment group (n=29). The control group was given conventional treatment of cerebral infarction, and the treatment group was given butylphthalide injection based on the conventional treatment. Two groups of patients underwent magnetic resonance imaging (MRI) scan on admission (first day), third day and tenth day, respectively. The cerebral infarction volume were measured. The serum matrix metalloproteinase-9 levels were detected at 12 hours, 48 hours, 72 hours after onset of disease. Results Comparing with the control group, the infarct volume of the treatment group at third day [(144.09±29.41)cm3vs(170.21±33.09)cm3]and tenth day[(116.57±25.73)cm3vs(140.21±29.48) cm3] were significantly reduced, which had statistical significance. Comparing with the control group, the serum matrix metalloproteinase-9 level decreased significantly in the treatment group at 48thhour and 72thhour after the onset of disease[48 h:(212.69±10.51)ng/ml vs(247.79±8.25)ng/ml);72 h:(86.14±4.84)ng/ml vs(106.10±7.03)ng/ml],which had statistical significance. Conclusion Butylphthalide injection can decrease the expression of matrix metalloproteinases-9 and reduce the volume of acute massive cerebral infarction.关键词
丁苯酞/大面积脑梗死/基质金属蛋白酶Key words
Butylphthalide/Massive cerebral infarction/Matrix metalloproteinase引用本文复制引用
王喜丰,李刚,付群芳,俞小梅,张静,汪敏,肖瑶,沈伟..丁苯酞注射液对急性大面积脑梗死体积及基质金属蛋白酶-9的影响[J].中国卒中杂志,2018,13(1):54-57,4.
