中华耳科学杂志2017，Vol.15Issue(6)：685-691,7.DOI:10.3969/j.issn.1672-2922.2017.06.016
RTOG推荐靶区与中国推荐靶区对T1-2期鼻咽癌IMRT计划内耳及耳蜗NTCP差异性研究
Differences in Inner Ear and Cochlear Normal Tissue Complication Probability between Target Volumes Recommended by Radiation Therapy Oncology Group and Those by China in Intensity-Modulated Radiotherapy for T1-2 Nasopharyngeal Carcinoma
摘要
Abstract
Objective To evaluate the differences in inner ear and cochlear normal tissue complication probability (NTCP)between target volumes recommended by China and those by Radiation Therapy Oncology Group(RTOG)for intensity-modulated radiotherapy for T1-2 nasopharyngeal carcinoma,to provide the dose-volume effect basis for protec-tion of the inner ear and cochlea.Methods A total of 20 patients with T1-2 nasopharyngeal carcinoma were identified,whose inner ears and cochleae were delineated on their CT images.Two sets of target volume delineation and treatment plan design were completed according to recommendations by the RTOG0225(RTOG methods)and to those by the Chi-nese Working Committee for Clinical Staging of Nasopharyngeal Carcinoma in 2010(Chinese methods).Radiation dos-age and NTCP were calculated for the inner ear and cochlea for both methods and the differences between the two meth-ods were compared.Results With the RTOG methods,the average radiation dosage(Dmean in cGy)was 4489±440 for the left inner ear,4339±749 for right inner ear,5109±396 for the left cochlea and 4855±774 for the right cochlea;while with the Chinese methods,the radiation dosages were 4039±482,3926±739,4584±474 and 4381±783,respectively,(P=0.000).With the RTOG methods,the maximum radiation dosage(Dmax in cGy)was 6369±355 for the left inner ear,6247±463 for the right inner ear,5794±354 for the left cochlea and 5616±562 for the right cochlea;whereas with the Chinese methods Dmax was 5901±426,5699±529,5230±387 and 5061±649,respectively,(P=0.000).With the RTOG methods,NTCP was 12(5.25-23.5)for the left inner ear,8(2.25-19.75)for the right inner ear,23.5(16.25-35.75)for the left cochlea and 14(6.25-33.75)for the right cochlea;whereas with the Chinese methods,NTCPs were 3.5(2-9.5),2.5 (1-8),9(5.25-16.75)and 6(1.25-12.5),respectively,(P=0.000-0.001).Conclusions For T1-2 nasopharyngeal carcino-ma,the inner ear NTCP is closely associated with the target volume dose and irradiated volume,but the cochlea NTCP,which has no obvious correlation with irradiated volume,is related with irradiated dose.Of the two target volume delin-eation methods,the inner ear and cochlear dose and NTCP determined by the Chinese method are significantly lower than those determined by the RTOG method.关键词
鼻咽肿瘤/调强放射疗法/耳蜗/内耳/正常组织并发症概率Key words
Nasopharynx Neoplasms/Intensity Modulated Radiotherapy/Cochlea/Inner Ear/Normal Tissue Com-plication Probability分类
医药卫生引用本文复制引用
钱建军,卢丽娜,田野,宦坚..RTOG推荐靶区与中国推荐靶区对T1-2期鼻咽癌IMRT计划内耳及耳蜗NTCP差异性研究[J].中华耳科学杂志,2017,15(6):685-691,7.基金项目
苏州市科技发展计划-产业技术创新专项(民生)科技-医疗卫生应用基础研究项目编号:(SYSD2016060) （民生）
国家自然基金面上项目(81372411)Suzhou science and technology development Program-Special project industrial technology innovation (SYSD2016060) （81372411）
National Natural Science Foundation of China(81372411) （81372411）
