重庆医学2018，Vol.47Issue(3)：294-298,5.DOI:10.3969/j.issn.1671-8348.2018.03.002
γ-H2AX的表达对初诊多发性骨髓瘤患者的预后影响
Influence of γ-H2AX expression on prognosis in patients with newly diagnosed multiple myeloma
摘要
Abstract
Objective To investigate the expression of bone marrow γ-H2AX in the patients with multiple myeloma(MM) and its correlation with the prognosis.Methods The patients with newly diagnosed MM in this hospital were selected as the case group,and the patients with non-hemopoietic system tumor without obvious morphological abnormalities by bone marrow smear and biopsy served as the control group.The immunohistochemistry was adopted to detect the expression level of bone marrow γ-H2AX in the cases group and control group,the image-Pro Plus(IPP) semiquantitative analysis was performed.The expression differences were compared between the two groups,moreover the case group was re-divided into the strong expression group and weak expression group according to γ-H2AX expression level.Then the relation ship between γ-H2AX expression level and the prognosis in the patients with MM.Results The bone marrow γ-H2AX expression level in the case group was significantly higher than that in the control group (P＜0.05);the level of γ-H2AX expression in the strong expression group was significantly stronger than that in the weak expression group (P＜0.05).Conclusion The level of γ-H2AX expression was higher among MM patients,and the over expression of γ-H2AX predicts the shorter survival time.关键词
多发性骨髓瘤/DNA断裂,双链/免疫组织化学/预后/γ-H2AXKey words
multiple myeloma/DNA breaks, double strand/immunohistochemistry/prognosis/γ-H2AX分类
医药卫生引用本文复制引用
曹春,张涛,杨岚,董宝侠,陈协群,高广勋,徐莉,冯娟,唐海龙,董红娟,顾宏涛,舒汨汨,白庆咸,梁蓉..γ-H2AX的表达对初诊多发性骨髓瘤患者的预后影响[J].重庆医学,2018,47(3):294-298,5.基金项目
国家自然科学基金资助项目(81172247) （81172247）
陕西省自然科学基础研究计划项目(2016JM8107 （）
2017JM8025) （）
陕西省社会发展科技攻关项目(2016SF-071). （2016SF-071）
