重庆医学2018，Vol.47Issue(3)：306-307,2.DOI:10.3969/j.issn.1671-8348.2018.03.005
真性红细胞增多症急性髓细胞白血病转化4例分析
Analysis on 4 cases of polycythemia vera transforming to acute myeloid leukemia
摘要
Abstract
Objective To explore the clinical characteristics,diagnosis and treatment of polycythemia vera(PV) transforming to acute myeloid leukemia(AML).Methods The clinical features and process of diagnosis and treatment in 4 cases of PV transforming to AML were analyzed.Results The case 1 had 10 years history of PV,after experiencing PV,had myelofibrosis and transformed to AML at the end stage of natural disease course;the case 2 had 7 years history of PV,orally took hydroxyurea(HU) treatment in recent 2 years and transformed to AML at present,his chromosome karyotype analysis showed 46,XY,del(7)(q31q36),del (18) (q22)[10],which was considered as treatment-related AML;the case 3 and 4 orally took H U for a long time after diagnosing HU,and respectively turned into AML during the pathologic polyemia stage after 6 and 7 years.Conclusion PV can be transformed to AML,the safety of HU in treatment should by paid attention to.关键词
红细胞增多症,真性/白血痛,髓样,急性/骨髓纤维化/骨硬化症/羟基脲Key words
polycythemia vera/leukemia, myeloid, acute/myelofibrosis/osteopetrosis/hydroxyurea分类
医药卫生引用本文复制引用
冶秀鹏,包慎,魏玉萍,智峰,郭营,李叶琼,宋丽君,牛玉捷,孙月..真性红细胞增多症急性髓细胞白血病转化4例分析[J].重庆医学,2018,47(3):306-307,2.基金项目
宁夏自然科学基金项目资助(NZ14185) （NZ14185）
中央高校基金项目资助(31920140074). （31920140074）
