重庆医学2018，Vol.47Issue(3)：308-310,315,4.DOI:10.3969/j.issn.1671-8348.2018.03.006
慢性粒细胞白血病加速期及急变期的形态学与免疫学分型的相关研究
Correlation research of morphology and immunological typing in acceleration phase and blastic phase of chronic myelogenous leukemia
邓小娟 1王平 1杨武晨 1墙星 1张洪洋 1彭贤贵1
作者信息
- 1. 第三军医大学新桥医院血液科,重庆400037
- 折叠
摘要
Abstract
Objective To explore the characteristics of morphology and immunology in acceleration phase and blastic phase of chronic myelogenous leukemia(CML).Methods Seventy-three cases of CML-BP bone marrow specimens were respectively conducted the morphology and related cell chemical dyeing observation for determining the FAB type.Flow cytometry was used to detect series immunological related antigens.Results Among 73 cases of FAB typing,there were 44 cases of CML-AML,21 cases of ALL and 8 cases.21 cases CML-ALL patients In the immunophenotyping by flow cytometry,among 21 cases of CML-ALL,there were 19 cases of B-ALL,2 cases of T-ALL,moreover 12 cases contained myeloid marker.Among 8 cases CML-HAL,the immunophenotypes were 6 cases of B+-My and 2 cases of T+ My.Among 44 cases CML-AML,15 cases contained T cell marker,and 2cases contained B cell marker,other cases had no cross-lineage expression.Among 73 cases of CML-BP,29 cases conducted the flow cytometry detection in the acceleration phase,in which 16 cases urgently changed to AML,and 13 cases to non-AML(9 cases of ALL and 4 cases of HAL).Among non-AML cases,2 cases had the simultaneous existence of myeloid primitive cells and precursor lymphocyte in the acceleration phase and other 9 cases were myeloid primitive cell or accompanied by lymphocyte marker.Conclusion Flow cytometry has a certain implication role for the direction and differentiation diagnosis of CML-BP.关键词
白血病,髓系,慢性,BCR-ABL阳性/白血病,髓样,加速期/细胞形态学/免疫表型分型Key words
leukemia, myelogenous, chronic, BCR-ABL positive/leukemia, myeloid, accelerated phase/cellular morphology/immunophenotyping分类
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邓小娟,王平,杨武晨,墙星,张洪洋,彭贤贵..慢性粒细胞白血病加速期及急变期的形态学与免疫学分型的相关研究[J].重庆医学,2018,47(3):308-310,315,4.
