重庆医学2018，Vol.47Issue(4)：436-438,445,4.DOI:10.3969/j.issn.1671-8348.2018.04.002
甘草甜素对体外诱导的酒精性脂肪肝细胞的影响及机制研究
Effects of glycyrrhizin on alcoholic fatty liver cells incluced in vitro and its mechanism
摘要
Abstract
Objective To investigate the effects of glycyrrhizin on the cell model of alcoholic fatty liver(AFL) induced in vitro and its possible mechanism.Methods The in vitro induced AFL cells were divided into the control group,separating ethanol group,glycyrrhizin group and continuous induction group.The levels of intracellular triglyceride(TG) and leakage amounts of ALT and AST,cell cycle change and protein and mRNA expressions of PPAR-γ,SREBP-1 and SCAP were measured.Results Glycyrrhizin could obviously reduce the apoptosis occurrence;compared with the control group,the level of intracellular TG and the leakage amounts of ALT and AST,and the protein and mRNA expressions of PPAR-γ,SREBP-1 and SCAP were significantly decreased(P＜0.05).Conclusion Glycyrrhizin may alleviate the fat change of in vitro induced AFL cells by down-regulating expressions of PPAR-γ,SREBP-1 and SCAP.关键词
甘草甜素/三酰甘油/脂肪肝,酒精性/丙氨酸转氨酶/天冬氨酸转氨酶Key words
glycyrrhizin/triglyceride/fatty liver,alcoholic/alanine transaminase/aspartate aminotransferase分类
医药卫生引用本文复制引用
卜晓芬,李骏,朱虹..甘草甜素对体外诱导的酒精性脂肪肝细胞的影响及机制研究[J].重庆医学,2018,47(4):436-438,445,4.基金项目
湖北省科技计划项目(2014CFB106). （2014CFB106）
