重庆医学2018，Vol.47Issue(4)：473-476,4.DOI:10.3969/j.issn.1671-8348.2018.04.012
RBP4对糖尿病肾病无症状脑梗死神经认知功能的影响
Effect of RBP4 on neurocognitive function in diabetic nephropathy with silent cerebral infarction
陈丹燕 1黄晓龙 2卢松 1邓华聪 3甘华 4杜晓刚 4王成剑 1黄荣曦 1张冰寒1
作者信息
- 1. 重庆市人民医院中山院区内分泌肾内科,重庆400013
- 2. 解放军第三二四医院神经外科,重庆400028
- 3. 重庆医科大学附属第一医院内分泌科,重庆400016
- 4. 重庆医科大学附属第一医院肾内科,重庆400016
- 折叠
摘要
Abstract
Objective To observe the impairment effect of retinol binding protein 4(RBP4) on neurocognitive function in diabetic nephropathy(DN) patients with silent cerebral infarction(SCI) and to explore its mechanism.Methods Sixty patients with newly diagnosed DN and 30 healthy volunteers were selected as the study subjects and the DN cases were divided into the complicating SCI group(SCI,n=30) and non-complicating SCI group(NSCI,n=30) according to the imaging results.The degrees of neurological function deficit and Montreal cognitive assessment(MoCA) were evaluated.Serum RBP4 level was determined by ELISA and expressions of Lp-PLA2 and C-X-C chemokine receptor type 4(CXCR4) were determined by Western blot.Results Compared with the NSCI group,the neurocognitive function in the SCI group was subsided,the expression levels of RBP4,Lp-PLA2 and CXCR4 were increased(P＜0.05).The RBP4 level was positively correlated with the neurocognitive function impairment in SCI patients,moreover,there existed a regression correlation between them.Conclusion Serum RBP4 may serve as the predictive factor of DN complicating SCI and is positively correlated with neurocognitive dysfunction.Lp-PLA2/CXCR4 pathway activation may be one of its pathogenesis.关键词
糖尿病肾病/无症状脑梗死/视黄醇结合蛋白4/功能损害/脂蛋白相关磷脂酶A2/受体,CXCR4Key words
diabetic nephropathies/silent cerebral infarction/retinol binding protein4/function impairment/lipoprotein-associated phospholipase A2/receptors, CXCR4分类
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陈丹燕,黄晓龙,卢松,邓华聪,甘华,杜晓刚,王成剑,黄荣曦,张冰寒..RBP4对糖尿病肾病无症状脑梗死神经认知功能的影响[J].重庆医学,2018,47(4):473-476,4.
