重庆医学2018，Vol.47Issue(4)：482-485,4.DOI:10.3969/j.issn.1671-8348.2018.04.015
尿液[TIMP-2]·[IGFBP-7]预测脓毒症患儿急性肾损伤的可行性研究
Study on feasibility of urinary TIMP-2 and IGFBP-7 for predicting acute kidney injury in pediatric patients with sepsis
肖琴 1郑静 1闫军2
作者信息
- 1. 四川省成都市妇女儿童中心医院PICU 610091
- 2. 重庆市九龙坡区人民医院儿科 400050
- 折叠
摘要
Abstract
Objective To explore the feasibility and accuracy of urinary tissue inhibitor of metalloproteinase-2(TIMP-2) and insulin-like growth factor binding protein-7(IGFBP-7) for predicting acute kidney injury(AKI) occurrence in pediatric patients with sepsis.Methods A total of 174 pediatric patients with sepsis in PICU of Chengdu Municipal Women and Children Central Hospital and 30 healthy control children(control group) from March 2014 to March 2017 were included.Fasting venous blood was collected at 8:00 every morning during 7 d before admitting to PICU for detecting serum SCr level;fresh urine sample was taken at 8:00 am and 20:00 pm.for detecting TIMP-2 and IGFBP-7 levels.The AKI was diagnosed according to KDIGO criteria in 2012.Thus the septic children patients were divided into the AKI group and non-AKI group.The receiver operating characteristic(ROC) curve and the area under the curve(AUC) were adopted to analyze the predictive value of TIMP-2 and IGFBP-7 at 12,24,36,48 h before diagnosis for AKI.Results Within 7 d in 174 children cases admitting to PICU,52 cases(29.89％) were diagnosed as AKI.The TIMP-2 and IGFBP-7 levels had no statistical difference between the non-AKI group and control group(P＞0.05).Urinary TIMP-2 and IGFBP-7 levels at 12,24,36 h before diagnosing AKI were significantly increased compared with those at admitting to PICU(P＜0.01);AUC of urinary TIMP-2 and IGFBP-7 levels for predicting AKI occurrence within following 12,24,36 h were 0.967 (95 ％CI:0.946-0.989),0.898(95％CI:0.844-0.951) and 0.748(95％CI:0.669-0.827) respectively,the difference was statistically significant(P＜0.01).Conclusion The urinary TIMP-2 and IGFBP-7 increase can more accurately predict AKI occurrence in pediatric patients with sepsis.关键词
急性肾损伤/分子标志物/金属蛋白酶组织抑制因子-2/胰岛素样生长因子结合蛋白-7/脓毒症Key words
acute kidney injury/molecular marker/tissue inhibitor of metalloproteinase-2/insulin-like growth factor binding protein-7/sepsis分类
医药卫生引用本文复制引用
肖琴,郑静,闫军..尿液[TIMP-2]·[IGFBP-7]预测脓毒症患儿急性肾损伤的可行性研究[J].重庆医学,2018,47(4):482-485,4.
