重庆医学2018，Vol.47Issue(4)：512-515,518,5.DOI:10.3969/j.issn.1671-8348.2018.04.023
布地奈德与福莫特罗同时用于哮喘控制和缓解治疗的Meta分析
Simultaneous use of budesonide and formoterol in asthma control and relieving therapy:a Meta analysis
摘要
Abstract
Objective To systematically assess the effectiveness and safety of simultaneously using budesonide(BUD) and formoterol(FORM) in asthma control and relieving therapy.Methods The databases including PubMed,Cochrane Library,EM-base,VIP,CNKI,CBM,Wanfang Data Knowledge Service Platform Database were retrieved by computer.The randomized controlled trials(RCTs) about BUD and FORM simultaneous use in asthma control and relieving therapy(observation group),BUD and FORM use in asthma control and terbutaline(TER) use in relieving therapy were collected in the various databases from their establishment to May 2017.The meta analysis was conducted by adopting the RevMan 5.3 software.Results A total of 5 RCTs(6 control groups) involving 10158 patients were included.The observation group was lower than the control group in the aspects of asthma aggravation admission or emergency person-times(OR=0.70,95％CI:0.59-0.85,P＜0.01),occurrence rate of serious adverse events(OR=0.66,95％CI:0.52-0.82,P＜0.01),occurrence rate of experiment termination by various causes[OR=0.84,95％CI:0.73-0.96,P=0.01);compared with the observation group,the improvement of night PEF value and FEV1 value after treatment in the control group was more significant (MD=4.05,95 ％ CI:0.18-7.93,P =0.04;MD =0.04,95 ％ CI:0.03-0.05,P＜0.01);the number of nocturnal awakening decrease times and occurrence rate of fatal adverse events had no statistically significant difference between the two groups[OR=1.25,95％CI:1.00-1.56,P=0.05;OR=1.01,95％CI:0.23-4.45,P=0.99).Conclusion BUD and FORM simultaneous use in asthma control and relieving therapy has an advantage in the aspects of reducing asthma acute attack and safety;BUD and FORM is used in asthma control,while TER is used in relieving therapy and has better effect for improving the lung function.关键词
哮喘/布地奈德/福莫特罗/Meta分析Key words
asthma/budesonide/formoterol/Meta analysis分类
医药卫生引用本文复制引用
谢叶红,路晓钦,董志..布地奈德与福莫特罗同时用于哮喘控制和缓解治疗的Meta分析[J].重庆医学,2018,47(4):512-515,518,5.基金项目
重庆市北碚区2015年第二批科技计划项目[碚科委发(2016)13号2015-56]. （2016）
