摘要
Abstract
Objective:To analyze the occurrence characteristics and laws of adverse drug reactions (ADR) in the Xinjiang Production and Construction Corps from 2014 to 2016 in order to reduce children's ADR incidence,to provide a scientific basis for clinical rational drug use.Methods:A total of 1,615 cases of ADR reported by Xinjiang Production and Construction Corps in 2014 to 2016 were retrospective statistically analyzed.Results:The incidence of ADR in children in Xinjiang Production and Construction Corps from 2014 to 2016 was on the rise.In 1,615 cases of ADR,new ADR accounted for 9.16％,and severe ADR accounted for 3.28％.Pharmacists (54.61％) and doctors (40.31％) were the main sources of ADR reports,and males (934 cases,57.83％) were more than females (681 cases,42.17％),but the difference was not statistically significant (P＞0.05).The 1 ～ 5 years old age group had the highest incidence of ADR (36.66％).Most of the ADRs were caused by antibacterial drugs (58.64％),and in the top 10 drugs cefuroxime was the first (8.98％).Intravenous drip was the most important route of administration of ADR,1,282 cases (79.38％).The most common clinical manifestations of ADR were skin and its appendages lesions (41.10％),mainly manifested as allergic reactions like rash,itching and macular papules.Most of the ADRs after correlation processing were recovered (56.16％),and improved (35.54％) Conclusion:Children's ADR appeared under the age of five years,with the intravenous drip to medicine,closely related to many factors such as the use of antimicrobial agents.Clinical indications should be strictly grasp the drug,drug delivery ways,dose,and to strengthen the importance of ADR monitoring work for children,reduce the incidence of ADR.关键词
儿童/药品不良反应/监测Key words
children/adverse drug reactions/monitoring分类
医药卫生
