摘要
Abstract
Objective To compared the efficacies of dezocine and midazolam on stability and inhibition of etomi -date emulsion-induced myoclonus and adverse reaction.Methods Forty-two patients with surgery under general anes-thesia,graded ASA I-II,aged 14-72 and weighted 44-80 kg were included.Using the random number table method, they were randomly divided into observation group(dezoncine)and the control group(imidazole).The blind method was applied in this study,as both anesthesia induction staff and observers for the myoclonus and adverse reaction were blin -ded.Intravenous administration of dezoncine(0.1 mg/kg)and imidazole diazepam(2 mg)were given in observation group and control group,respectively.The dizziness within the 5 seconds after injection were recorded.The etomidate was given within 20-30 s,and subsequent myoclonus was recorded.Ninety seconds after the injection of etomidate, sufen-tanil(0.3-0.4 μg/kg)and rocuronium(0.6-0.9 mg/kg)were given.Visual laryngoscope endotracheal intubation was performed.BP and HR were recorded at T0,T1 and T2.The adverse reactions before and after intubation were also recorded.Results Compared with those at T0,the SBP,DBP and HR at T1 in observation group were significantly de-clined(P<0.01),and the DBP and HR in both observation group and control group were significantly increased at T 2 (P<0.05,P<0.01).Compared with control group,the HR and SBP in observation group at T 2 and T1 was significant-ly reduced(P<0.05).No myoclonus was reported in observation group,while there was 6 cases of myoclonus were ob-served in control group,including 3 cases with mild myoclonus,1 case with moderate myoclonus and 2 cases with severe myoclonus.The myoclonus rate was significantly higher in control group(P<0.01), so was the incidence of tears after endotracheal intubation(P<0.05).Conclusion Dezocine is more effective in inhibiting etomidate emulsion -induced myoclonus,strengthening the anesthesia effect,and reducing the intubation response than imidazole.关键词
地佐辛/依托咪酯/肌阵挛Key words
dezocine/etomidate/myoclonu
