广东医学2018，Vol.39Issue(1)：84-87,4.
S100 B基因rs9722和rs2186358遗传多态性在广西人群中的分布
The distribution of the S100B gene rs9722 and rs2186358 polymorphism in Guangxi populations
摘要
Abstract
Objective To study the distribution characteristics of S100B gene rs9722 and rs2186358 polymor-phism in Guangxi population,and to compare the distribution differences among different ethnics.Methods Polymerase chain reaction-single base extension(SBE-PCR)and DNA sequencing were used to detect the genotype of S 100B gene among 398 individuals in Guangxi,China.The results were compared with the reported frequencies in four other popula-tions(Hap Map-CEU,Hap Map-YRI, Hap Map-ASW and Hap Map-HCB)from Human Genome Project group (Hap Map)data,to analyze the distributional differences among rs 9722,rs2186358 polymorphism and alleles frequencies of five different races.Results There was no significant difference in genotype or allele frequencies of rs 9722 and rs2186358 among the male and female in Guangxi population(P>0.05).The genotype and allele frequency of S 100B gene rs9722 in Guangxi population showed significant difference as compared with Hap Map -CEU,Hap Map-YRI,Hap Map-ASW and Hap Map-HCB(P<0.05).The genotype and allele frequency of rs 2186358 showed statistically signif-icant differences as compared with Hap Map -CEU,Hap Map-YRI,Hap Map-ASW(P<0.05).The genotype fre-quency of rs2186358 showed significant difference as compared with Hap Map -HCB(P<0.05), however, the allele frequency of rs2186358 showed no significant difference as compared with Hap Map -HCB(P>0.05).Conclusion The distribution of S100B gene polymorphisms in this Guangxi population is different from those in other ethnic popula -tions,and this variation might contribute for a variety of clinical manifestation and morbidity of S 100B related diseases.关键词
S100B/基因多态性/种族Key words
S100B/gene polymorphism/race引用本文复制引用
陆玉兰,黄华佗,王荣,覃海媚,刘纯宏,向阳,韦叶生..S100 B基因rs9722和rs2186358遗传多态性在广西人群中的分布[J].广东医学,2018,39(1):84-87,4.基金项目
国家自然科学基金资助项目(编号:81560552,81260234),广西研究生教育创新计划项目(编号:YCSW2017213) （编号:81560552,81260234）
